α-Alkyl cysteine-coated gold nanoparticles: effect of Cα-tetrasubstitution on colloidal stability

被引：7

作者：

Osante, Inaki ^{[1
]}

Polo, Ester ^{[2
]}

Revilla-Lopez, Guillermo ^{[3
]}

de la Fuente, Jesus M. ^{[2
]}

Aleman, Carlos ^{[3
,4
]}

Cativiela, Carlos ^{[1
]}

Diaz Diaz, David ^{[1
,5
,6
]}

机构：

[1] Univ Zaragoza, CSIC, ISQCH, E-50009 Zaragoza, Spain

[2] Univ Zaragoza, Inst Nanociencia Aragon, Zaragoza, Spain

[3] Univ Politecn Cataluna, Dept Engn Quim, ETSEIB, E-08028 Barcelona, Spain

[4] Univ Politecn Cataluna, Ctr Res Nanoengn, E-08028 Barcelona, Spain

[5] CSIC, IQAC, ES-08034 Barcelona, Spain

[6] Univ Regensburg, Fak Chem & Pharm, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2014年 / 16卷 / 02期

基金：

奥地利科学基金会;

关键词：

Gold nanoparticles; Cysteine; C alpha-tetrasubstitution; Colloidal stability; Molecular dynamics; Modeling and simulation;

D O I：

10.1007/s11051-013-2224-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we report the synthesis of new alpha-methyl L-cysteine-coated gold nanoparticles (average core diameter ca. 3 nm) and the remarkable enhancement of their aqueous stability against aggregation in comparison with the nanoparticles capped with unmodified L-cysteine under the same experimental conditions. Atomistic molecular dynamics simulations of model gold surfaces capped with L-cysteine or alpha-methyl L-cysteine revealed important differences in both the organization of the amino acids with respect to the surface and their spontaneous assembly with neighboring molecules. These differences, which are originated by the introduction of the alpha-methyl group in the amino acid, could be associated with the observed increase in stability and dispersibility of the composites in aqueous solutions at different pH values and ionic concentrations.

引用

页数：12

共 51 条

[31] Effect of gold nanoparticles as a support for the oligomerization of L-cysteine in an aqueous solution [J].