Genomic and epigenetic insights into the molecular bases of heterosis

被引:408
作者
Chen, Z. Jeffrey [1 ,2 ,3 ]
机构
[1] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA
[2] Univ Texas Austin, Ctr Computat Biol & Bioinformat, Austin, TX 78712 USA
[3] Nanjing Agr Univ, Natl Lab Plant Genet & Germplasm Enhancement, Nanjing 210095, Jiangsu, Peoples R China
基金
美国国家科学基金会; 美国国家卫生研究院; 中国国家自然科学基金;
关键词
ARABIDOPSIS CIRCADIAN CLOCK; DIRECTED DNA METHYLATION; QUANTITATIVE TRAIT LOCUS; GENE-EXPRESSION; RNA-POLYMERASE; ALLELIC VARIATION; HISTONE MODIFICATIONS; NUCLEOLAR DOMINANCE; NATURAL VARIATION; WIDE ANALYSIS;
D O I
10.1038/nrg3503
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Heterosis, also known as hybrid vigour, is widespread in plants and animals, but the molecular bases for this phenomenon remain elusive. Recent studies in hybrids and allopolyploids using transcriptomic, proteomic, metabolomic, epigenomic and systems biology approaches have provided new insights. Emerging genomic and epigenetic perspectives suggest that heterosis arises from allelic interactions between parental genomes, leading to altered programming of genes that promote the growth, stress tolerance and fitness of hybrids. For example, epigenetic modifications of key regulatory genes in hybrids and allopolyploids can alter complex regulatory networks of physiology and metabolism, thus modulating biomass and leading to heterosis. The conceptual advances could help to improve plant and animal productivity through the manipulation of heterosis.
引用
收藏
页码:471 / 482
页数:12
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