Postoperative peripheral blood monocyte count correlates with postoperative bile leakage in patients with colorectal liver metastases after hepatic resection

被引：6

作者：

Haruki, Koichiro ^{[1
]}

Shiba, Hiroaki ^{[1
]}

Fujiwara, Yuki ^{[1
]}

Furukawa, Kenei ^{[1
]}

Wakiyama, Shigeki ^{[1
]}

Ogawa, Masaichi ^{[1
]}

Ishida, Yuichi ^{[1
]}

Misawa, Takeyuki ^{[1
]}

Yanaga, Katsuhiko ^{[1
]}

机构：

[1] Jikei Univ, Sch Med, Dept Surg, Minato Ku, Tokyo 1058461, Japan

来源：

LANGENBECKS ARCHIVES OF SURGERY | 2013年 / 398卷 / 06期

关键词：

Colorectal liver metastases; Bile leakage; Monocyte; Hepatic resection; COLONY-STIMULATING FACTOR; STEM-CELL FACTOR; RISK-FACTORS; REGENERATION; MANAGEMENT; HEPATECTOMY; SCORE; MODEL; MICE;

D O I：

10.1007/s00423-013-1083-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Postoperative bile leakage is one of the most common complications after hepatic surgery. The relationship between the inflammatory response and postoperative bile leakage has not been fully investigated. Therefore, we retrospectively investigated the relation between postoperative peripheral blood monocyte count and bile leakage in patients with colorectal liver metastases (CRLM) after elective hepatic resection. The study comprised 105 patients who had undergone hepatic resection for CRLM between January 2000 and March 2012. Perioperative risk factors pertinent to development of bile leakage were investigated using univariate and multivariate analyses. Bile leakage developed in 9 (8.6 %) of 105 patients. In multivariate analysis, intraoperative fresh frozen plasma (FFP) transfusion (p = 0.009) and lower monocyte count of the peripheral blood on postoperative day 1 (p = 0.038) were found as independent risk factors of bile leakage. Postoperative lower monocyte count and intraoperative FFP transfusion were associated with the development of postoperative bile leakage after elective hepatic resection in patients with CRLM.

引用

页码：851 / 855

页数：5

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