Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives

被引：52

作者：

Fouda, Ahmed M. ^{[1
]}

Abbas, Hebat-Allah S. ^{[1
,2
]}

Ahmed, Eman H. ^{[1
]}

Shati, Ali A. ^{[3
]}

Alfaifi, Mohammad Y. ^{[3
]}

Elbehairi, Serag Eldin I. ^{[3
,4
]}

机构：

[1] King Khalid Univ, Chem Dept, Fac Sci, Abha 9004, Saudi Arabia

[2] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt

[3] King Khalid Univ, Biol Dept, Fac Sci, Abha 9004, Saudi Arabia

[4] Egyptian Org Biol Prod & Vaccines VACSERA Holding, Cell Culture Lab, 51 Wezaret El Zeraa St, Giza 12311, Egypt

来源：

MOLECULES | 2019年 / 24卷 / 06期

关键词：

pyrazole; 3; 5-diaminopyrazole; pyrazolo[1; 5-a]pyrimidine; microwave; antimicrobial; antitumor activities; BIOLOGICAL EVALUATION; DESIGN;

D O I：

10.3390/molecules24061080

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of pyrazole 4-7 and pyrazolo[1,5-a]pyrimidine 8-13 were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-a]pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control.

引用

页数：20

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