Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis

被引：70
作者：
Seyedmousavi, Seyedmojtaba [1 ,2 ]
Mouton, Johan W. [1 ,2 ]
Verweij, Paul E. [1 ,2 ]
Bruggemann, Roger J. M. [2 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
[2] Nijmegen Inst Infect Inflammat & Immun, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Dept Pharm, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源：
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2013年 / 11卷 / 09期
关键词：
Aspergillus; azole antifungal drugs; pharmacodynamics; pharmacokinetics; therapeutic drug monitoring; POPULATION PHARMACOKINETIC ANALYSIS; EXPOSURE-RESPONSE RELATIONSHIP; IN-VITRO ACTIVITIES; AMPHOTERICIN-B; MURINE MODEL; PLASMA-CONCENTRATIONS; FUNGAL-INFECTIONS; EFFICACY; SAFETY; PROPHYLAXIS;
D O I：
10.1586/14787210.2013.826989
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Voriconazole and posaconazole are extended-spectrum triazoles recommended for treatment, prophylaxis and salvage therapy of Aspergillus diseases. Over the past decade many papers have emerged supporting the use of therapeutic drug monitoring (TDM) for azole antifungals. TDM is used to tailor the exposure of a specific drug to the individuals to optimize treatment response and minimize side effects. We reviewed the pharmacokinetics and pharmacodynamics (PK-PD) characteristics of voriconazole and posaconazole. We present the available evidence on target concentrations defining maximal efficacy and minimal toxicity. Finally we provide some practical recommendations how to best perform TDM in clinical practice.
引用
收藏
页码：931 / 941
页数：11
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