Otosclerosis From Genetics to Molecular Biology

被引：26
作者：
Babcock, Thomas A. [1 ]
Liu, Xue Zhong [1 ]
机构：
[1] Univ Miami, Miller Sch Med, Dept Otolaryngol, 1120 NorthWest 14th St,5th Floor, Miami, FL 33136 USA
来源：
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2018年 / 51卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Otosclerosis; Otic capsule; Genetics; Gene; Pathophysiology; ANGIOTENSIN-ALDOSTERONE SYSTEM; DRINKING-WATER FLUORIDATION; MEASLES-VIRUS; OTIC CAPSULE; IN-VITRO; RECEPTOR EXPRESSION; SODIUM-FLUORIDE; BONE TURNOVER; NO EVIDENCE; LOCUS;
D O I：
10.1016/j.otc.2017.11.002
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.
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页码：305 / +
页数：15
相关论文
共 80 条
[51]   The pathophysiology of otosclerosis: Review of current research [J].
Rudic, M. ;
Keogh, I. ;
Wagner, R. ;
Wilkinson, E. ;
Kiros, N. ;
Ferrary, E. ;
Sterkers, O. ;
Grayeli, A. Bozorg ;
Zarkovic, K. ;
Zarkovic, N. .
HEARING RESEARCH, 2015, 330 :51-56
[52]   The effects of angiotensin II and the oxidative stress mediator 4-hydroxynonenal on human osteoblast-like cell growth: possible relevance to otosclerosis [J].
Rudic, Milan ;
Milkovic, Lidija ;
Zarkovic, Kamelija ;
Borovic-Sunjic, Suzana ;
Sterkers, Olivier ;
Waeg, Georg ;
Ferrary, Evelyne ;
Grayeli, Alexis Bozorg ;
Zarkovic, Neven .
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 57 :22-28
[53]   Effect of Angiotensin II on Inflammation Pathways in Human Primary Bone Cell Cultures in Otosclerosis [J].
Rudic, Milan ;
Nguyen, Christine ;
Nguyen, Yann ;
Milkovic, Lidija ;
Zarkovic, Neven ;
Sterkers, Olivier ;
Ferrary, Evelyne ;
Grayeli, Alexis Bozorg .
AUDIOLOGY AND NEURO-OTOLOGY, 2012, 17 (03) :169-178
[54]   A new locus for otosclerosis, OTSC10, maps to chromosome 1q41-44 [J].
Schrauwen, I. ;
Weegerink, N. J. D. ;
Fransen, E. ;
Claes, C. ;
Pennings, R. J. E. ;
Cremers, C. W. R. J. ;
Huygen, P. L. M. ;
Kunst, H. P. M. ;
Van Camp, G. .
CLINICAL GENETICS, 2011, 79 (05) :495-497
[55]   Involvement of T-cell receptor-β alterations in the development of otosclerosis linked to OTSC2 [J].
Schrauwen, I. ;
Venken, K. ;
Vanderstraeten, K. ;
Thys, M. ;
Hendrickx, J-J ;
Fransen, E. ;
Van Laer, L. ;
Govaerts, P. J. ;
Verstreken, M. ;
Schatteman, I. ;
Stinissen, P. ;
Hellings, N. ;
Van Camp, G. .
GENES AND IMMUNITY, 2010, 11 (03) :246-253
[56]  
Schrauwen I, 2008, J BONE MINER RES, V23, P507, DOI [10.1359/jbmr.071112, 10.1359/JBMR.071112]
[57]   The Etiology of Otosclerosis: A Combination of Genes and Environment [J].
Schrauwen, Isabelle ;
Van Camp, Guy .
LARYNGOSCOPE, 2010, 120 (06) :1195-1202
[58]   No Evidence for Association Between the Renin-Angiotensin-Aldosterone System and Otosclerosis in a Large Belgian-Dutch Population [J].
Schrauwen, Isabelle ;
Thys, Melissa ;
Vanderstraeten, Kathleen ;
Fransen, Erik ;
Ealy, Megan ;
Cremers, Cor W. R. J. ;
Dhooge, Ingeborg ;
Van de Heyning, Paul ;
Offeciers, Erwin ;
Smith, Richard J. H. ;
Van Camp, Guy .
OTOLOGY & NEUROTOLOGY, 2009, 30 (08) :1079-1083
[59]   Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations [J].
Schrauwen, Isabelle ;
Ealy, Megan ;
Fransen, Erik ;
Vanderstraeten, Kathleen ;
Thys, Melissa ;
Meyer, Nicole C. ;
Cosgarea, Marcel ;
Huber, Alex ;
Mazzoli, Manuela ;
Pfister, Markus ;
Smith, Richard J. H. ;
Van Camp, Guy .
HUMAN GENETICS, 2010, 127 (02) :155-162
[60]   A Genome-wide Analysis Identifies Genetic Variants in the RELN Gene Associated with Otosclerosis [J].
Schrauwen, Isabelle ;
Ealy, Megan ;
Huentelman, Matthew J. ;
Thys, Melissa ;
Homer, Nils ;
Vanderstraeten, Kathleen ;
Fransen, Erik ;
Corneveaux, Jason J. ;
Craig, David W. ;
Claustres, Mireille ;
Cremers, Cor W. R. J. ;
Dhooge, Ingeborg ;
de Heyning, Paul Van ;
Vincent, Robert ;
Offeciers, Erwin ;
Smith, Richard J. H. ;
Van Camp, Guy .
AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (03) :328-338
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