Otosclerosis From Genetics to Molecular Biology

被引：26

作者：

Babcock, Thomas A. ^{[1
]}

Liu, Xue Zhong ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Otolaryngol, 1120 NorthWest 14th St,5th Floor, Miami, FL 33136 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2018年 / 51卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Otosclerosis; Otic capsule; Genetics; Gene; Pathophysiology; ANGIOTENSIN-ALDOSTERONE SYSTEM; DRINKING-WATER FLUORIDATION; MEASLES-VIRUS; OTIC CAPSULE; IN-VITRO; RECEPTOR EXPRESSION; SODIUM-FLUORIDE; BONE TURNOVER; NO EVIDENCE; LOCUS;

D O I：

10.1016/j.otc.2017.11.002

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Over the past several years, with the evolution of genetic and molecular research, several etiologic factors have been implicated in the pathogenesis of otosclerosis. Overall, current evidence suggests that otosclerosis is a complex disease with a variety of potential pathways contributing to the development of abnormal bone remodeling in the otic capsule. These pathways involved in the pathogenesis of otosclerosis are influenced by both genetic and environmental factors.

引用

页码：305 / +

页数：15

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