An updated review of the H19 lncRNA in human cancer: molecular mechanism and diagnostic and therapeutic importance

被引：61

作者：

Alipoor, Behnam ^{[1
]}

Parvar, Seyedeh Nasrin ^{[2
]}

Sabati, Zolfaghar ^{[3
]}

Ghaedi, Hamid ^{[4
]}

Ghasemi, Hassan ^{[5
]}

机构：

[1] Yasuj Univ Med Sci, Fac Paramed, Dept Lab Sci, Yasuj, Iran

[2] Yasuj Univ Med Sci, Fac Med, Dept Biochem, Yasuj, Iran

[3] Abadan Fac Med Sci, Student Res Comm, Abadan, Iran

[4] Shahid Beheshti Univ Med Sci, Fac Med, Dept Med Genet, Tehran, Iran

[5] Abadan Fac Med Sci, Dept Clin Biochem, Abadan, Iran

来源：

MOLECULAR BIOLOGY REPORTS | 2020年 / 47卷 / 08期

关键词：

Cancer; Long non-coding RNA; H19; Biomarker; miRNA sponging; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-CYCLE PROGRESSION; BREAST-CANCER; TUMOR-SUPPRESSOR; C-MYC; HEPATOCELLULAR-CARCINOMA; MIR-200; FAMILY; GASTRIC-CANCER; LUNG-CANCER;

D O I：

10.1007/s11033-020-05695-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence has reported that H19 long non-coding RNA (lncRNA) expression level is deregulated in human cancer. It has been also demonstrated that de-regulated levels of H19 could affect cancer biology by various mechanisms including microRNA (miRNA) production (like miR-675), miRNA sponging and epigenetic modifications. Furthermore, lncRNA could act as a potential diagnosis and prognosis biomarkers and also a candidate therapeutic approach for different human cancers. In this narrative review, we shed light on the molecular mechanism of H19 in cancer development and pathogenesis. Moreover, we discussed the expression pattern and diagnostic and therapeutic importance of H19 as a potential biomarker in a range of human malignancies from breast to osteosarcoma cancer.

引用

页码：6357 / 6374

页数：18

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