Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes

被引：79

作者：

Fujisawa, Keiko ^{[1
]}

Katakami, Naoto ^{[1
,2
]}

Kaneto, Hideaki ^{[1
]}

Naka, Toyoko ^{[1
]}

Takahara, Mitsuyoshi ^{[1
]}

Sakamoto, Fumie ^{[1
]}

Irie, Yoko ^{[1
]}

Miyashita, Kazuyuki ^{[1
]}

Kubo, Fumiyo ^{[1
]}

Yasuda, Tetsuyuki ^{[1
]}

Matsuoka, Taka-aki ^{[1
]}

Shimomura, Iichiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

ATHEROSCLEROSIS | 2013年 / 227卷 / 02期

关键词：

sRAGE; RAGE; Cardiovascular event; Atherosclerosis; Type; 2; diabetes; GLYCATION END-PRODUCTS; CORONARY-ARTERY-DISEASE; ENDPRODUCTS RAGE; RECEPTOR; ATHEROSCLEROSIS; ASSOCIATION; SRAGE; FORM;

D O I：

10.1016/j.atherosclerosis.2013.01.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：425 / 428

页数：4

共 50 条

[41] Cardiovascular risk factors and mitral annular calcification in type 2 diabetes [J].

Qasim, Atif N. ;

Rafeek, Hashmi ;

Rasania, Suraj P. ;

Churchill, Timothy W. ;

Yang, Wei ;

Ferrari, Victor A. ;

Jha, Saurabh ;

Master, Stephen M. ;

Mulvey, Claire K. ;

Terembula, Karen ;

Dailing, Chris ;

Budoff, Matthew J. ;

Kawut, Steven M. ;

Reilly, Muredach P. .

ATHEROSCLEROSIS, 2013, 226 (02) :419-424

[42] Major Adverse Cardiovascular Events and Mortality Prediction by Circulating GDF-15 in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis [J].

Xie, Suyi ;

Li, Qi ;

Luk, Andrea O. Y. ;

Lan, Hui-Yao ;

Chan, Paul K. S. ;

Bayes-Genis, Antoni ;

Chan, Francis K. L. ;

Fung, Erik .

BIOMOLECULES, 2022, 12 (07)

[43] Role of endogenous secretory RAGE (esRAGE) in defending against plaque formation induced by oxidative stress in type 2 diabetic patients [J].

Piarulli, Francesco ;

Lapolla, Annunziata ;

Ragazzi, Eugenio ;

Susana, Angela ;

Sechi, Annalisa ;

Nollino, Laura ;

Cosma, Chiara ;

Fedele, Domenico ;

Sartore, Giovanni .

ATHEROSCLEROSIS, 2013, 226 (01) :252-257

[44] The Interaction of Dietary Patterns and Genetic Variants on the Risk of Cardiovascular Diseases in Chinese Patients with Type 2 Diabetes [J].

Zhang, Shiwen ;

Chen, Shiyun ;

He, Kaiyin ;

Liu, Jiazi ;

Su, Xin ;

Li, Wanlin ;

Ma, Junrong ;

Cheng, Chen ;

Ouyang, Ruiqing ;

Mu, Yingjun ;

Zheng, Lu ;

Cai, Jun ;

Feng, Yonghui ;

Zeng, Fangfang ;

Peng, Longyun ;

Ye, Yanbin .

MOLECULAR NUTRITION & FOOD RESEARCH, 2023, 67 (22)

[45] Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes [J].

Aubert, C. E. ;

Michel, P. -L. ;

Gillery, P. ;

Jaisson, S. ;

Fonfrede, M. ;

Morel, F. ;

Hartemann, A. ;

Bourron, O. .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2014, 30 (08) :679-685

[46] Vascular or chronological age: which is the better marker to estimate the cardiovascular risk in patients with type 1 diabetes? [J].

Moraes de Andrade, Carlos Roberto, Jr. ;

Clemente Silva, Eliete Leao ;

Bevilaqua da Matta, Maria de Fatima ;

Castier, Marcia Bueno ;

Garcia Rosa, Maria Luiza ;

Gomes, Marilia Brito .

ACTA DIABETOLOGICA, 2016, 53 (06) :925-933

[47] Effect of G(-174)C polymorphism in interleukin-6 gene on cardiovascular disease in type 2 diabetes patients [J].

Buraczynska, Monika ;

Zukowski, Pawel ;

Drop, Bartlomiej ;

Baranowicz-Gaszczyk, Iwona ;

Ksiazek, Andrzej .

CYTOKINE, 2016, 79 :7-11

[48] Erythrocyte membrane fluidity: A novel biomarker of residual cardiovascular risk in type 2 diabetes [J].

Bianchetti, Giada ;

Cefalo, Chiara Maria Assunta ;

Ferreri, Carla ;

Sansone, Anna ;

Vitale, Marilena ;

Serantoni, Cassandra ;

Abeltino, Alessio ;

Mezza, Teresa ;

Ferraro, Pietro Manuel ;

De Spirito, Marco ;

Riccardi, Gabriele ;

Giaccari, Andrea ;

Maulucci, Giuseppe .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2024, 54 (03)

[49] Effect of Physical Activity on Cardiovascular Event Risk in a Population-Based Cohort of Patients with Type 2 Diabetes [J].

Enguita-German, Monica ;

Tamayo, Ibai ;

Galbete, Arkaitz ;

Librero, Julian ;

Cambra, Koldo ;

Ibanez-Beroiz, Berta .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (23)

[50] The potential of colchicine for lowering the risk of cardiovascular events in type 1 diabetes [J].

Johansen, Nicklas Jarvela ;

Knop, Filip Krag .

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 2023, 9 (04) :311-317

← 1 2 3 4 5 →