Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes

被引：80

作者：

Fujisawa, Keiko ^{[1
]}

Katakami, Naoto ^{[1
,2
]}

Kaneto, Hideaki ^{[1
]}

Naka, Toyoko ^{[1
]}

Takahara, Mitsuyoshi ^{[1
]}

Sakamoto, Fumie ^{[1
]}

Irie, Yoko ^{[1
]}

Miyashita, Kazuyuki ^{[1
]}

Kubo, Fumiyo ^{[1
]}

Yasuda, Tetsuyuki ^{[1
]}

Matsuoka, Taka-aki ^{[1
]}

Shimomura, Iichiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

ATHEROSCLEROSIS | 2013年 / 227卷 / 02期

关键词：

sRAGE; RAGE; Cardiovascular event; Atherosclerosis; Type; 2; diabetes; GLYCATION END-PRODUCTS; CORONARY-ARTERY-DISEASE; ENDPRODUCTS RAGE; RECEPTOR; ATHEROSCLEROSIS; ASSOCIATION; SRAGE; FORM;

D O I：

10.1016/j.atherosclerosis.2013.01.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：425 / 428

页数：4

共 50 条

[31] Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes [J].

Nowak, Christoph ;

Carlsson, Axel C. ;

Ostgren, Carl Johan ;

Nystrom, Fredrik H. ;

Alam, Moudud ;

Feldreich, Tobias ;

Sundstrom, Johan ;

Carrero, Juan-Jesus ;

Leppert, Jerzy ;

Hedberg, Par ;

Henriksen, Egil ;

Cordeiro, Antonio C. ;

Giedraitis, Vilmantas ;

Lind, Lars ;

Ingelsson, Erik ;

Fall, Tove ;

Arnlov, Johan .

DIABETOLOGIA, 2018, 61 (08) :1748-1757

[32] Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes [J].

Nakamura, Kazuo ;

Yamagishi, Sho-ichi ;

Adachi, Hisashi ;

Matsui, Takanori ;

Kurita-Nakamura, Yayoi ;

Takeuchi, Masayoshi ;

Inoue, Hiroyoshi ;

Imaizumi, Tsutomu .

MICROVASCULAR RESEARCH, 2008, 76 (01) :52-56

[33] Iranian Risk Model as a Predictive Tool for Retinopathy in Patients with Type 2 Diabetes [J].

Azizi-Soleiman, Fatemeh ;

Heidari-Beni, Motahar ;

Ambler, Gareth ;

Omar, Rumana ;

Amini, Masoud ;

Hosseini, Sayed-Mohsen .

CANADIAN JOURNAL OF DIABETES, 2015, 39 (05) :358-363

[34] Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus [J].

Biswas, Subrata Kumar ;

Mohtarin, Sabreena ;

Mudi, Sonchita Rani ;

Anwar, Taznuva ;

Banu, Laila Anjuman ;

Alam, Sheikh Md Khorshed ;

Fariduddin, Md ;

Arslan, M. Iqbal .

JOURNAL OF DIABETES RESEARCH, 2015, 2015

[35] RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes [J].

Wendt, T ;

Harja, E ;

Bucciarelli, L ;

Wu, Q ;

Lu, Y ;

Rong, LL ;

Jenkins, DG ;

Stein, G ;

Schmidt, AM ;

Yan, SF .

ATHEROSCLEROSIS, 2006, 185 (01) :70-77

[36] Network analytics and machine learning for predictive risk modelling of cardiovascular disease in patients with type 2 diabetes [J].

Hossain, Ekramul ;

Uddin, Shahadat ;

Khan, Arif .

EXPERT SYSTEMS WITH APPLICATIONS, 2021, 164

[37] Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study [J].

Jacopo Sabbatinelli ;

Stefania Castiglione ;

Federica Macrì ;

Angelica Giuliani ;

Deborah Ramini ;

Maria Cristina Vinci ;

Elena Tortato ;

Anna Rita Bonfigli ;

Fabiola Olivieri ;

Angela Raucci .

Cardiovascular Diabetology, 21

[38] Advanced serum lipoprotein and glycoprotein profiling for cardiovascular event prediction in type 2 diabetes mellitus: the LIPOCAT study [J].

Amigo, Nuria ;

Castelblanco, Esmeralda ;

Julve, Josep ;

Martinez-Micaelo, Neus ;

Alonso, Nuria ;

Hernandez, Marta ;

Ribalta, Josep ;

Guardiola, Montse ;

Toran-Monserrat, Pere ;

Lopez-Lifante, Victor ;

Herrero-Alonso, Cecilia ;

Arteaga, Ingrid ;

Ortega, Emilio ;

Franch-Nadal, Josep ;

Mauricio, Didac .

CARDIOVASCULAR DIABETOLOGY, 2025, 24 (01)

[39] Endocan is Related to Increased Cardiovascular Risk in Type 2 Diabetes Mellitus Patients [J].

Klisic, Aleksandra ;

Kotur-Stevuljevic, Jelena ;

Ninic, Ana .

METABOLIC SYNDROME AND RELATED DISORDERS, 2023, 21 (07) :362-369

[40] Comparison of effects of pioglitazone and glimepiride on plasma soluble RAGE and RAGE expression in peripheral mononuclear cells in type 2 diabetes: Randomized controlled trial (PioRAGE) [J].

Koyama, Hidenori ;

Tanaka, Shinji ;

Monden, Masayo ;

Shoji, Takuhito ;

Morioka, Tomoaki ;

Fukumoto, Shinya ;

Mori, Katsuhito ;

Emoto, Masanori ;

Shoji, Tetsuo ;

Fukui, Mitsuru ;

Fujii, Hisako ;

Nishizawa, Yoshiki ;

Inaba, Masaaki .

ATHEROSCLEROSIS, 2014, 234 (02) :329-334

← 1 2 3 4 5 →