Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes

被引：80

作者：

Fujisawa, Keiko ^{[1
]}

Katakami, Naoto ^{[1
,2
]}

Kaneto, Hideaki ^{[1
]}

Naka, Toyoko ^{[1
]}

Takahara, Mitsuyoshi ^{[1
]}

Sakamoto, Fumie ^{[1
]}

Irie, Yoko ^{[1
]}

Miyashita, Kazuyuki ^{[1
]}

Kubo, Fumiyo ^{[1
]}

Yasuda, Tetsuyuki ^{[1
]}

Matsuoka, Taka-aki ^{[1
]}

Shimomura, Iichiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

ATHEROSCLEROSIS | 2013年 / 227卷 / 02期

关键词：

sRAGE; RAGE; Cardiovascular event; Atherosclerosis; Type; 2; diabetes; GLYCATION END-PRODUCTS; CORONARY-ARTERY-DISEASE; ENDPRODUCTS RAGE; RECEPTOR; ATHEROSCLEROSIS; ASSOCIATION; SRAGE; FORM;

D O I：

10.1016/j.atherosclerosis.2013.01.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：425 / 428

页数：4

共 14 条

[11] Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts [J].

Park', L ;

Raman, KG ;

Lee, KJ ;

Lu, Y ;

Ferran, LJ ;

Chow, WS ;

Stern, D ;

Schmidt, AM .

NATURE MEDICINE, 1998, 4 (09) :1025-1031

[12] A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) [J].

Raucci, Angela ;

Cugusi, Simona ;

Antonelli, Antonella ;

Barabino, Silvia M. ;

Monti, Lucilla ;

Bierhaus, Angelika ;

Reiss, Karina ;

Saftig, Paul ;

Bianchi, Marco E. .

FASEB JOURNAL, 2008, 22 (10) :3716-3727

[13] RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (AGES) HAS A CENTRAL ROLE IN-VESSEL WALL INTERACTIONS AND GENE ACTIVATION IN RESPONSE TO CIRCULATING AGE PROTEINS [J].

SCHMIDT, AM ;

HASU, M ;

POPOV, D ;

ZHANG, JH ;

CHEN, JX ;

YAN, SD ;

BRETT, J ;

CAO, R ;

KUWABARA, K ;

COSTACHE, G ;

SIMIONESCU, N ;

SIMIONESCU, M ;

STERN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :8807-8811

[14] Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes [J].

Stern, DM ;

Du Yan, S ;

Yan, SF ;

Schmidt, AM .

AGEING RESEARCH REVIEWS, 2002, 1 (01) :1-15

← 1 2 →