Compatibility study between trandolapril and natural excipients used in solid dosage forms

被引：25
|
作者：
Roumeli, Eleftheria [1 ]
Tsiapranta, Angelina [2 ]
Pavlidou, Eleni [1 ]
Vourlias, Georgios [1 ]
Kachrimanis, Kyriakos [1 ,2 ]
Bikiaris, Dimitrios [3 ]
Chrissafis, Konstantinos
机构：
[1] Aristotle Univ Thessaloniki, Dept Phys, Solid State Phys Sect, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Pharm, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, Dept Chem, Lab Organ Chem Technol, Thessaloniki 54124, Greece
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2013年 / 111卷 / 03期
关键词：
Trandolapril; Excipients; Compatibility studies; Thermogravimetric analysis; Differential scanning calorimetry; DIFFERENTIAL SCANNING CALORIMETRY; THERMAL-ANALYSIS; STABILITY; NAPROXEN; LACTOSE;
D O I：
10.1007/s10973-012-2476-2
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Thermal analysis is an essential, analytic tool used in preliminary studies and preparation of new pharmaceutical formulations. This study was performed to investigate the possible interactions between trandolapril and three commonly used natural excipients, namely alpha-lactose monohydrate, microcrystalline cellulose, and pregelatinized starch. The compatibility studies were carried out using thermoanalytic along with other complementary techniques. Differential scanning calorimetry and thermogravimetric analysis have proved that trandolapril is fully compatible with all the studied excipients until 100 A degrees C. The complementary techniques used in this study were X-ray powder diffraction, Fourier transform-infrared spectroscopy, and scanning electron microscopy which confirmed the findings of thermal analysis.
引用
收藏
页码：2109 / 2115
页数：7
相关论文
共 50 条
  • [41] Biocompatibility investigation of different pharmaceutical excipients used in liquid dosage forms
    Nemes, D.
    Ujhelyi, Z.
    Arany, P.
    Peto, A.
    Feher, P.
    Varadi, J.
    Fenyvesi, F.
    Vecsernyes, M.
    Bacskay, I
    PHARMAZIE, 2018, 73 (01): : 16 - 18
  • [42] Update on compatibility assessment of empagliflozin with the selected pharmaceutical excipients employed in solid dosage forms by thermal, spectroscopic and chromatographic techniques
    Niguram, Prakash
    Polaka, Surya Narayana
    Rathod, Rajeshwari
    Kalia, Kiran
    Kate, Abhijeet S.
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2020, 46 (02) : 209 - 218
  • [43] Surface Active Agents as Excipients in Semi-Solid Dosage Forms
    Musial, Witold
    Szewczyk, Ewa
    Karlowicz-Bodalska, Katarzyna
    Han, Stanislaw
    ROMANIAN BIOTECHNOLOGICAL LETTERS, 2015, 20 (02): : 10257 - 10268
  • [44] Compatibility study between diazepam and tablet excipients
    Matos, A. P. S.
    Costa, J. S.
    Boniatti, J.
    Seiceira, R. C.
    Pitaluga, A., Jr.
    Oliveira, D. L.
    Vicosa, A. L.
    Holandino, C.
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2017, 127 (02) : 1675 - 1682
  • [45] DISSOLUTION AND COMPATIBILITY CONSIDERATIONS FOR USE OF MANNITOL IN SOLID DOSAGE FORMS
    WARD, DR
    LATHROP, LB
    LYNCH, MJ
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1969, 58 (12) : 1464 - &
  • [46] Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations
    Stulzer, H. K.
    Rodrigues, P. O.
    Cardoso, T. M.
    Matos, J. S. R.
    Silva, M. A. S.
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2008, 91 (01) : 323 - 328
  • [47] Compatibility study of dry extract of Ximenia americana L. and pharmaceutical excipients used in solid state
    Cleildo P. Santana
    Felipe H. A. Fernandes
    Deysiane O. Brandão
    Paulo César D. Silva
    Lidiane P. Correia
    Fernanda P. Nóbrega
    Francinalva D. de Medeiros
    Paulo Henrique G. D. Diniz
    Germano Véras
    Ana Cláudia D. Medeiros
    Journal of Thermal Analysis and Calorimetry, 2018, 133 : 603 - 617
  • [48] Compatibility study of dry extract of Ximenia americana L. and pharmaceutical excipients used in solid state
    Santana, Cleildo P.
    Fernandes, Felipe H. A.
    Brandao, Deysiane O.
    Silva, Paulo Cesar D.
    Correia, Lidiane P.
    Nobrega, Fernanda P.
    de Medeiros, Francinalva D.
    Diniz, Paulo Henrique G. D.
    Veras, Germano
    Medeiros, Ana Claudia D.
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2018, 133 (01) : 603 - 617
  • [49] Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations
    H. K. Stulzer
    P. O. Rodrigues
    T. M. Cardoso
    J. S. R. Matos
    M. A. S. Silva
    Journal of Thermal Analysis and Calorimetry, 2008, 91 : 323 - 328
  • [50] Interactions Analysis between Furazolidone and Excipients used in Pharmaceutical Forms
    Marian, Eleonora
    Jurca, Tunde
    Kacso, Irina
    Miclaus, Maria
    Bratu, Ioana
    REVISTA DE CHIMIE, 2013, 64 (11): : 1275 - 1278
12345