Compatibility study between trandolapril and natural excipients used in solid dosage forms

被引：25
|
作者：
Roumeli, Eleftheria [1 ]
Tsiapranta, Angelina [2 ]
Pavlidou, Eleni [1 ]
Vourlias, Georgios [1 ]
Kachrimanis, Kyriakos [1 ,2 ]
Bikiaris, Dimitrios [3 ]
Chrissafis, Konstantinos
机构：
[1] Aristotle Univ Thessaloniki, Dept Phys, Solid State Phys Sect, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Pharm, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, Dept Chem, Lab Organ Chem Technol, Thessaloniki 54124, Greece
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2013年 / 111卷 / 03期
关键词：
Trandolapril; Excipients; Compatibility studies; Thermogravimetric analysis; Differential scanning calorimetry; DIFFERENTIAL SCANNING CALORIMETRY; THERMAL-ANALYSIS; STABILITY; NAPROXEN; LACTOSE;
D O I：
10.1007/s10973-012-2476-2
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Thermal analysis is an essential, analytic tool used in preliminary studies and preparation of new pharmaceutical formulations. This study was performed to investigate the possible interactions between trandolapril and three commonly used natural excipients, namely alpha-lactose monohydrate, microcrystalline cellulose, and pregelatinized starch. The compatibility studies were carried out using thermoanalytic along with other complementary techniques. Differential scanning calorimetry and thermogravimetric analysis have proved that trandolapril is fully compatible with all the studied excipients until 100 A degrees C. The complementary techniques used in this study were X-ray powder diffraction, Fourier transform-infrared spectroscopy, and scanning electron microscopy which confirmed the findings of thermal analysis.
引用
收藏
页码：2109 / 2115
页数：7
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