Analysis of blood-based gene expression signature in first-episode psychosis

被引：17

作者：

Lee, Jimmy ^{[1
,2
,3
]}

Goh, Liang-Kee ^{[4
,5
,6
]}

Chen, Gengbo ^{[4
]}

Verma, Swapna ^{[7
]}

Tan, Chay-Hoon ^{[8
]}

Lee, Tih-Shih ^{[9
]}

机构：

[1] Woodbridge Hosp, Inst Mental Hlth, Dept Gen Psychiat 1, Singapore 539747, Singapore

[2] Woodbridge Hosp, Inst Mental Hlth, Div Res, Singapore 539747, Singapore

[3] Duke Natl Univ Singapore, Grad Sch Med, Off Clin Sci, Singapore, Singapore

[4] Duke Natl Univ Singapore, Grad Sch Med, Canc & Stem Cell Biol Program, Singapore, Singapore

[5] Natl Canc Ctr Singapore, Dept Med Oncol, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore

[7] Woodbridge Hosp, Inst Mental Hlth, Dept Early Psychosis Intervent, Singapore 539747, Singapore

[8] Natl Univ Hlth Syst, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore, Singapore

[9] Duke Natl Univ Singapore, Grad Sch Med, Neurosci & Behav Disorders Program, Singapore, Singapore

来源：

PSYCHIATRY RESEARCH | 2012年 / 200卷 / 01期

关键词：

Transcriptome; First-episode psychosis; Blood; MICROARRAY;

D O I：

10.1016/j.psychres.2012.03.021

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Blood-based transcriptomic signature in psychosis is an alternative to a brain-based signature. In this study, we profiled whole-blood RNA from 26 patients with first-episode psychosis, and 26 matching controls. We identified a 400-gene signature that classified patients from controls accurately and tested the robustness using other modelling methods. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 54

页数：3

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