Analysis of blood-based gene expression signature in first-episode psychosis

被引：17
|
作者：
Lee, Jimmy [1 ,2 ,3 ]
Goh, Liang-Kee [4 ,5 ,6 ]
Chen, Gengbo [4 ]
Verma, Swapna [7 ]
Tan, Chay-Hoon [8 ]
Lee, Tih-Shih [9 ]
机构：
[1] Woodbridge Hosp, Inst Mental Hlth, Dept Gen Psychiat 1, Singapore 539747, Singapore
[2] Woodbridge Hosp, Inst Mental Hlth, Div Res, Singapore 539747, Singapore
[3] Duke Natl Univ Singapore, Grad Sch Med, Off Clin Sci, Singapore, Singapore
[4] Duke Natl Univ Singapore, Grad Sch Med, Canc & Stem Cell Biol Program, Singapore, Singapore
[5] Natl Canc Ctr Singapore, Dept Med Oncol, Singapore, Singapore
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore
[7] Woodbridge Hosp, Inst Mental Hlth, Dept Early Psychosis Intervent, Singapore 539747, Singapore
[8] Natl Univ Hlth Syst, Dept Pharmacol, Yong Loo Lin Sch Med, Singapore, Singapore
[9] Duke Natl Univ Singapore, Grad Sch Med, Neurosci & Behav Disorders Program, Singapore, Singapore
来源：
PSYCHIATRY RESEARCH | 2012年 / 200卷 / 01期
关键词：
Transcriptome; First-episode psychosis; Blood; MICROARRAY;
D O I：
10.1016/j.psychres.2012.03.021
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Blood-based transcriptomic signature in psychosis is an alternative to a brain-based signature. In this study, we profiled whole-blood RNA from 26 patients with first-episode psychosis, and 26 matching controls. We identified a 400-gene signature that classified patients from controls accurately and tested the robustness using other modelling methods. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：52 / 54
页数：3
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