Interstitial cells of Cajal in the gut - A gastroenterologist's point of view

被引:30
作者
Negreanu, Lucian M. [1 ,2 ]
Assor, Philippe [2 ]
Mateescu, Bogdan [3 ]
Cirstoiu, Catalin [4 ]
机构
[1] Univ Hosp Bucharest, Dept Gastroenterol, Bucharest 050098, Romania
[2] Trousseau Univ, Ctr Hosp, Dept Hepatogastroenterol, F-37044 Tours, France
[3] Colentina Hosp, Dept Gastroenterol, Bucharest 020125, Romania
[4] Univ Hosp Bucharest, Orthoped & Surg Dept, Bucharest 050098, Romania
关键词
Cajal cells; c-kit; Intestinal motility; Achalasia; Gastrointestinal stromal tumor;
D O I
10.3748/wjg.14.6285
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract. (C) 2008 The WJG Press. All rights reserved.
引用
收藏
页码:6285 / 6288
页数:4
相关论文
共 40 条
[1]   The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis [J].
Ando, N ;
Goto, H ;
Niwa, Y ;
Hirooka, Y ;
Ohmiya, N ;
Nagasaka, T ;
Hayakawa, T .
GASTROINTESTINAL ENDOSCOPY, 2002, 55 (01) :37-43
[2]   Cerebellar degeneration and hearing loss in a patient with idiopathic myenteric ganglionitis [J].
Basilisco, G ;
Gebbia, C ;
Peracchi, M ;
Velio, P ;
Conte, D ;
Bresolin, N ;
Nobile-Orazio, E .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2005, 17 (04) :449-452
[3]  
CAJAL SR, 1995, HIST NERVOUS SYSTEM, P891
[4]  
Coulie B, 1999, ANNU REV MED, V50, P37
[5]  
D'Amato Gina, 2005, Cancer Control, V12, P44
[6]   Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction [J].
De Giorgio, R ;
Sarnelli, G ;
Corinaldesi, R ;
Stanghellini, V .
GUT, 2004, 53 (11) :1549-1552
[7]   New insights into human enteric neuropathies [J].
De Giorgio, R ;
Guerrini, S ;
Barbara, G ;
Cremon, C ;
Stanghellini, V ;
Corinaldesi, R .
NEUROGASTROENTEROLOGY AND MOTILITY, 2004, 16 :143-147
[8]   Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with imatinib [J].
de Silva, MV ;
Reid, R .
PATHOLOGY & ONCOLOGY RESEARCH, 2003, 9 (01) :13-19
[9]   Selective knockout of intramuscular interstitial cells reveals their role in the generation of slow waves in mouse stomach [J].
Dickens, EJ ;
Edwards, FR ;
Hirst, GDS .
JOURNAL OF PHYSIOLOGY-LONDON, 2001, 531 (03) :827-833
[10]  
FAUSSONEPELLEGRINI MS, 1985, J SUBMICR CYTOL PATH, V17, P673