2-Substituted 3-arylindoles through palladium-catalyzed arylative cyclization of 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions

被引：45

作者：

Arcadi, Antonio ^{[1
]}

Cacchi, Sandro ^{[2
]}

Fabrizi, Giancarlo ^{[2
]}

Goggiamani, Antonella ^{[2
]}

Iazzetti, Antonia ^{[2
]}

Marinelli, Fabio ^{[1
]}

机构：

[1] Univ Aquila, Dipartimento Sci Fis & Chim, I-67010 Laquila, Italy

[2] Univ Rome, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 04期

关键词：

O-ALKYNYLTRIFLUOROACETANILIDES; 2,3-DISUBSTITUTED INDOLES; COUPLING REACTIONS; HECK REACTIONS; SUZUKI; ARYL; FUNCTIONALIZATION; METHODOLOGIES; NANOCATALYSTS; DERIVATIVES;

D O I：

10.1039/c2ob27125g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups.

引用

页码：545 / 548

页数：4

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