Modulating Osteoimmune Responses by Mesoporous Silica Nanoparticles

被引：21

作者：

Hosseinpour, Sepanta ^{[1
]}

Walsh, Laurence J. ^{[1
]}

Xu, Chun ^{[1
]}

机构：

[1] Univ Queensland, Sch Dent, Herston, Qld 4006, Australia

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2022年 / 8卷 / 10期

基金：

英国医学研究理事会;

关键词：

immunomodulation; osteoimmunomodulation; bone regeneration; mesoporous silica nanoparticles; macrophages; CERIUM DIOXIDE NANOPARTICLES; M2 MACROPHAGE POLARIZATION; PROTEIN-KINASE PATHWAYS; FACTOR-KAPPA-B; IN-VITRO; OSTEOBLAST DIFFERENTIATION; INFLAMMATORY RESPONSES; TRICALCIUM PHOSPHATE; CELLULAR-RESPONSE; OXIDATIVE STRESS;

D O I：

10.1021/acsbiomaterials.1c00899

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The immune response plays an important role in biomaterial-mediated osteogenesis. Nanomaterials may influence immune responses and thereby alter bone regeneration. Mesoporous silica nanoparticles (MSNs) have received much attention for drug delivery and bone regeneration. Recently, immunomodulatory effects of MSNs on osteogenesis have been reported. In this Review, we summarize the osteoimmunomodulation of MSNs, including the effects of MSN characteristics on immune cells and osteogenesis. Impacts of MSNs on immune cells vary according to nanoparticle properties, including surface topography and charge, particle size, and ion release. MSNs with suitable doses can inhibit inflammation and create an immune microenvironment beneficial for bone regeneration by activating immune cells and stimulating cytokine release. Further work is needed to explore and clarify the underlying mechanisms, including crosstalk between various types of immune cells and how to design MSNs to create a suitable immune environment for osteogenesis.

引用

页码：4110 / 4122

页数：13

共 119 条

[1] Core-Shell-structured Dendritic Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Antibody Delivery [J].