Collagen: a network for regenerative medicine

被引：144

作者：

Pawelec, K. M. ^{[1
]}

Best, S. M. ^{[2
]}

Cameron, R. E. ^{[2
]}

机构：

[1] Univ Michigan, 2350 Hayward Ave, Ann Arbor, MI 48109 USA

[2] Univ Cambridge, Cambridge Ctr Med Mat, Cambridge CB3 0FS, England

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 40期

基金：

欧洲研究理事会;

关键词：

CROSS-LINKING; EXTRACELLULAR-MATRIX; MECHANICAL-PROPERTIES; SPATIAL-ORGANIZATION; CELL INVASION; LYSYL OXIDASE; IN-VITRO; FIBRILLOGENESIS; SCAFFOLDS; BINDING;

D O I：

10.1039/c6tb00807k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential.

引用

页码：6484 / 6496

页数：13

共 121 条

[1] Effect of 1-ethyl -3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair [J].

Ahmad, Zafar ;

Shepherd, Jennifer H. ;

Shepherd, David V. ;

Ghose, Siddhartha ;

Kew, Simon J. ;

Cameron, Ruth E. ;

Best, Serena M. ;

Brooks, Roger A. ;

Wardale, John ;

Rushton, Neil .

REGENERATIVE BIOMATERIALS, 2015, 2 (02) :77-85

[2] Nanocomposites from biopolymer hydrogels: Blueprints for white biotechnology and green materials chemistry [J].

Aime, Carole ;

Coradin, Thibaud .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2012, 50 (10) :669-680

[3] Novel porous scaffolds of pH responsive chitosan/carrageenan-based polyelectrolyte complexes for tissue engineering [J].

Araujo, J. V. ;

Davidenko, N. ;

Danner, M. ;

Cameron, R. E. ;

Best, S. M. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (12) :4415-4426

[4] Skeletal diseases caused by mutations that affect collagen structure and function [J].

Arnold, William V. ;

Fertala, Andrzej .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2013, 45 (08) :1556-1567

[5]

Ashworth JC, 2016, TISSUE ENG PART C-ME, V22, P409, DOI [10.1089/ten.tec.2015.0483, 10.1089/ten.TEC.2015.0483]

[6] Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory [J].

Ashworth, Jennifer C. ;

Mehr, Marco ;

Buxton, Paul G. ;

Best, Serena M. ;

Cameron, Ruth E. .

ADVANCED HEALTHCARE MATERIALS, 2015, 4 (09) :1317-1321

[7] The supramolecular organization of collagen VI microfibrils [J].

Baldock, C ;

Sherratt, MJ ;

Shuttleworth, CA ;

Kielty, CM .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 330 (02) :297-307

[8] Fibrillogenesis from nanosurfaces: multiphoton imaging and stereological analysis of collagen 3D self-assembly dynamics [J].

Bancelin, Stephane ;

Decenciere, Etienne ;

Machairas, Vaia ;

Albert, Claire ;

Coradin, Thibaud ;

Schanne-Klein, Marie-Claire ;

Aime, Carole .

SOFT MATTER, 2014, 10 (35) :6651-6657

[9] Integrins [J].

Barczyk, Malgorzata ;

Carracedo, Sergio ;

Gullberg, Donald .

CELL AND TISSUE RESEARCH, 2010, 339 (01) :269-280

[10] pH-responsive collagen fibrillogenesis in confined droplets induced by vapour diffusion [J].

Belen Ramirez-Rodriguez, Gloria ;

Iafisco, Michele ;

Tampieri, Anna ;

Gomez-Morales, Jaime ;

Manuel Delgado-Lopez, Jose .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2014, 25 (10) :2305-2312

← 1 2 3 4 5 6 7 8 9 10 →