Porous collagen-apatite nanocomposite foams as bone regeneration scaffolds

被引：115

作者：

Pek, Y. S. ^{[1
]}

Gao, Shujun ^{[1
]}

Arshad, M. S. Mohamed ^{[1
]}

Leck, Kwong-Joo ^{[1
]}

Ying, Jackie Y. ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

来源：

BIOMATERIALS | 2008年 / 29卷 / 32期

关键词：

Biomimetic material; Bone healing; Hydroxyapatite; Nanocomposite; Scaffold;

D O I：

10.1016/j.biomaterials.2008.07.030

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We have created a porous bioresorbable nanocomposite bone scaffold that chemically, structurally and mechanically matched natural bone so that it could be recognized and remodeled by natural bone. Containing collagen fibers and synthetic apatite nanocrystals, our scaffold has high strength for supporting the surrounding tissue. The foam-like scaffold has a similar microstructure as trabecular bone, with nanometer-sized and micron-sized pores. The apatitic phase of the scaffold exhibited similar chemical composition, crystalline phase and grain size as the trabecular bone apatite. The nanocomposite scaffold demonstrated excellent bioactivity for promoting cell attachment and proliferation. It was osteoconductive and successfully healed a non-union fracture in rat femur as well as a critical-sized defect in pig tibia. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4300 / 4305

页数：6

共 40 条

[1] Nanostructure processing of hydroxyapatite-based bioceramics [J].

Ahn, ES ;

Gleason, NJ ;

Nakahira, A ;

Ying, JY .

NANO LETTERS, 2001, 1 (03) :149-153

[2] The effect of zirconia reinforcing agents on the microstructure and mechanical properties of hydroxyapatite-based nanocomposites [J].

Ahn, ES ;

Gleason, NJ ;

Ying, JY .

JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2005, 88 (12) :3374-3379

[3]

BELL E, 2001, Patent No. 6179872

[4]

BELL E, 1999, Patent No. 5891558

[5]

BELL E, 2000, Patent No. 6153292

[6] Preparation of a porous hydroxyapatite/collagen nanocomposite using glutaraldehyde as a crosslinkage agent [J].

Chang, MC ;

Ikoma, T ;

Kikuchi, M ;

Tanaka, J .

JOURNAL OF MATERIALS SCIENCE LETTERS, 2001, 20 (13) :1199-1201

[7]

CULLITY BD, 1985, ELEMENTS XRAY DIFFRA, P101

[8] BONE-GRAFT AND BONE-GRAFT SUBSTITUTES - A REVIEW OF CURRENT TECHNOLOGY AND APPLICATIONS [J].

DAMIEN, CJ ;

PARSONS, JR .

JOURNAL OF APPLIED BIOMATERIALS, 1991, 2 (03) :187-208

[9] Cross-linking of dermal sheep collagen using a water-soluble carbodiimide [J].

Damink, LHHO ;

Dijkstra, PJ ;

vanLuyn, MJA ;

vanWachem, PB ;

Nieuwenhuis, P ;

Feijen, J .

BIOMATERIALS, 1996, 17 (08) :765-773

[10]

Dennis J E, 1992, Cell Transplant, V1, P23

← 1 2 3 4 →