AAV-mediated CYP46A1 delivery is beneficial in Alzheimer's disease models: towards a clinical application

被引:0
|
作者
Alves, S. [1 ]
Michaelsen-Preusse, K. [2 ]
Audrain, M. [1 ]
Aron-Badin, R. [3 ]
Lamaziere, A. [4 ]
Fol, R. [1 ]
Braudeau, J. [1 ]
Despres, G. [4 ]
Fouquet, F. [1 ]
Pradier, L. [5 ]
Delatour, B. [6 ]
Korte, M. [2 ]
Hantraye, P. [3 ]
Aubourg, P. [1 ]
Cartier, N. [1 ]
机构
[1] CEA, INSERM, U1169, MIRCen, Fontenay Aux Roses, France
[2] TU Braunschweig, Div Cellular Neurobiol, Inst Zool, Braunschweig, Germany
[3] CEA, DSV, I2BM, MIRCen, F-92265 Fontenay Aux Roses, France
[4] Sorbonne Univ, INSERM, ERL 1157, Pierre & Marie Curie Paris 6, Paris, France
[5] Sanofi, Neurodegenerat & Pain Unit, Chilly Mazarin, France
[6] CNRS, UMR 7225, INSERM, U1127,Inst Cerveau & Moelle Epiniere, Paris, France
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
P005
引用
收藏
页码:A47 / A47
页数:1
相关论文
共 50 条
  • [31] CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease
    Boussicault, Lydie
    Alves, Sandro
    Lamaziere, Antonin
    Planques, Anabelle
    Heck, Nicolas
    Moumne, Lara
    Despres, Gaetan
    Bolte, Susanne
    Hu, Amelie
    Pages, Christiane
    Galvan, Laurie
    Piguet, Francoise
    Aubourg, Patrick
    Cartier, Nathalie
    Caboche, Jocelyne
    Betuing, Sandrine
    BRAIN, 2016, 139 : 953 - 970
  • [32] STRIATAL REGULATION OF CHOLESTEROL METABOLISM BY CYP46A1 IS ASSOCIATED WITH MULTIPLE BENEFITS IN HUNTINGTON'S DISEASE KNOCK-IN MICE MODELS
    Kacher, Radhia
    Kappes, Vincent
    Lamaziere, Antonin
    Heck, Nicolas
    Despres, Gaetan
    Dembitskaia, Luliia
    Perrin, Elodie
    Christaller, Wilhem
    Nair, Satish Sasidharan
    Messent, Valerie
    Venance, Laurent
    Saudou, Frederic
    Neri, Christian
    Vanhoutte, Peter
    Caboche, Jocelyne
    Betuing, Sandrine
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2018, 89 : A93 - A93
  • [33] The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson's disease
    Dai, Lijun
    Wang, Jiannan
    Meng, Lanxia
    Zhang, Xingyu
    Xiao, Tingting
    Deng, Min
    Chen, Guiqin
    Xiong, Jing
    Ke, Wei
    Hong, Zhengyuan
    Bu, Lihong
    Zhang, Zhentao
    PLOS BIOLOGY, 2025, 23 (02)
  • [34] Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEε3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
    del Pozo, VF
    Alvarez, MA
    Martínez, MF
    Alcelay, LG
    Busto, FG
    Peña, JA
    Alfonso-Sánchez, MA
    Imirizaldu, JJZ
    de Pancorbo, MM
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 21 (02) : 81 - 87
  • [35] BENEFICIAL EFFECTS OF STRIATAL RESTORATION OF CYP46A1 EXPRESSION ON CHOLESTEROL METABOLISM AND NEURODEGENERATION IN HUNTINGTON'S DISEASE MOUSE MODEL (R6/2)
    Betuing, S.
    Planques, A.
    Moumne, L.
    Lamazieres, A.
    Boussicault, L.
    Pages, C.
    Aubourg, P.
    Cartier, N.
    Caboche, J.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 : A17 - A18
  • [36] Systemic delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of Machado-Joseph disease: a promising therapeutic strategy
    Serra, B.
    Duarte, S. P.
    Cartier, N.
    Alves, S.
    de Almeida, L. P.
    Perfeito, R.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A85 - A85
  • [37] Investigating the Effects of Brain Cholesterol Metabolism Using CYP46A1 Gene Therapy in Subjects with Huntington's Disease
    Schultz, Meredith
    Durr, Alexandra
    Karachi, Carine
    O'Callaghan, Michael
    Alves, Sandro
    Lamontagne, Alain
    Hurmic, Hortense
    Cartier, Nathalie
    NEUROLOGY, 2023, 100 (17)
  • [38] Beneficial effects of striatal restoration of CYP46A1 expression using AAVrh10 serotype in Huntington's disease mice model (R6/2)
    Planques, Anabelle
    Hu, Amelie
    Piguet, Francoise
    Moumne, Lara
    Djelti, Fathia
    Mailly, Philippe
    Cartier, Nathalie
    Aubourg, Patrick
    Caboche, Jocelyne
    Betuing, Sandrine
    HUMAN GENE THERAPY, 2012, 23 (10) : A73 - A73
  • [39] AAV-Mediated APOE4 Gene Silencing to Treat Homozygous APOE4-Associated Alzheimer's Disease
    Karan, Kalpita R.
    Kebret, Mara R.
    Hackett, Neil R.
    Crystal, Ronald G.
    MOLECULAR THERAPY, 2024, 32 (04) : 533 - 533
  • [40] AAV-CYP46A1 brain administration restores cholesterol metabolism and is neuroprotective in Huntington's disease
    Cartier, N.
    Boussicault, L.
    Alves, S.
    Kacher, R.
    Lamaziere, A.
    Planques, A.
    Heck, N.
    Moumne, L.
    Despres, G.
    Boltes, S.
    Hu, A.
    Pages, C.
    Galvan, L.
    Piguet, F.
    Aubourg, P.
    Caboche, J.
    Betuing, S.
    HUMAN GENE THERAPY, 2016, 27 (11) : A24 - A24