Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications

被引：51

作者：

Sher, Gulab ^{[1
]}

Salman, Nadia Aziz ^{[2
]}

Khan, Abdul Q. ^{[1
]}

Prabhu, Kirti S. ^{[1
]}

Raza, Afsheen ^{[3
]}

Kulinski, Michal ^{[1
]}

Dermime, Said ^{[3
]}

Haris, Mohammad ^{[4
,5
]}

Junejo, Kulsoom ^{[6
]}

Uddin, Shahab ^{[1
,7
]}

机构：

[1] Hamad Med Corp, Translat Res Inst, Acad Hlth Syst, POB 3050, Doha, Qatar

[2] Kingston Univ London, SEC Fac, Sch Life Sci Pharm & Chem, London KT1 2EE, England

[3] Hamad Med Corp, Natl Ctr Canc Care & Res, POB 3050, Doha, Qatar

[4] Sidra Med, Funct & Mol Imaging Lab, POB 26999, Doha, Qatar

[5] Qatar Univ, Lab Anim Res Ctr, POB 2713, Doha, Qatar

[6] Hamad Med Corp, Gen Surg Dept, Hamad Gen Hosp, POB 3050, Doha, Qatar

[7] Hamad Med Corp, Dermatol Inst, Acad Hlth Syst, POB 3050, Doha, Qatar

来源：

SEMINARS IN CANCER BIOLOGY | 2022年 / 83卷

关键词：

Epigenetics; Breast cancer; DNA methylation; Epigenetic drugs; Biomarkers; LONG NONCODING RNA; DNA METHYLATION PROFILES; TUMOR MICROENVIRONMENT; ABERRANT METHYLATION; HISTONE DEACETYLASES; CELLS; RESISTANCE; GENE; EXPRESSION; BIOMARKERS;

D O I：

10.1016/j.semcancer.2020.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechanism of BC pathogenesis and its hallmarks include drug resistance and stemness features. The understanding of these modifications and their significance in the management of BC carcinogenesis is challenging and requires further attention. Nevertheless, it promises to provide novel insight needed for utilizing these alterations as potential diagnostic, prognostic markers, predict treatment efficacy, as well as therapeutic agents. This highlights the importance of continuing research development to further advance the existing knowledge on epigenetics and BC carcinogenesis to overcome the current challenges. Hence, this review aims to shed light and discuss the current state of epigenetics research in the diagnosis and management of BC.

引用

页码：152 / 165

页数：14

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