Circulating thrombopoietin level in chronic immune thrombocytopenic purpura

被引：173

作者：

Kosugi, S

Kurata, Y

Tomiyama, Y

Tahara, T

Kato, T

Tadokoro, S

Shiraga, M

Honda, S

Kanakura, Y

Matsuzawa, Y

机构：

[1] OSAKA UNIV HOSP, DEPT BLOOD TRANSFUS, SUITA, OSAKA, JAPAN

[2] OSAKA UNIV, SCH MED, DEPT INTERNAL MED 2, OSAKA, JAPAN

[3] KIRIN BREWERY CO LTD, PHARMACEUT RES LAB, MAEBASHI, GUMMA, JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 93卷 / 03期

关键词：

thrombopoietin; ITP; aplastic anaemia;

D O I：

10.1046/j.1365-2141.1996.d01-1702.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The circulating thrombopoietin (TPO) level in 43 patients with chronic immune thrombocytopenic purpura (ITP) was examined by an ELISA system. The TPO level (mean +/- SD) in ITT patients was mildly elevated (1.86 +/- 1.17 fmol/ml) compared to that in normal subjects (0.76 +/- 0.21), and was within the normal range in 30% of ITP patients. In contrast, the TPO level in patients with aplastic anaemia was very high, 12.35 +/- 6.42 fmol/ml. There was no correlation between TPO level and platelet count in ITP patients. Splenectomy was performed in two ITP patients, after which platelet counts increased to normal levels and TPO levels showed a transient increase. These data suggest that reactive TPO production against thrombocytopenia in ITP is small when compared to that in aplastic anaemia. Relative endogenous TPO deficiency may play some role in the pathophysiology of thrombocytopenia in ITP patients.

引用

页码：704 / 706

页数：3

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