A framework based on isogeometric analysis is presented for parametrizing a wind turbine rotor blade and evaluating its response. The framework consists of a multi-fidelity approach for wind turbine rotor analysis. The aeroelastic loads are determined using a low-fidelity model. The model is based on isogeometric approach to model both the structural and aerodynamic properties. The structural deformations are solved using an isogeometric formulation of geometrically exact 3D beam theory. The aerodynamic loads are calculated using a standard Blade Element Momentum(BEM) theory. Moreover, the aerodynamic loads calculated using BEM theory are modified to account for the change in the blade shape due to blade deformation. The aeroelastic loads are applied in finite element solver Nastran, and both the stress response and buckling response are extracted. Furthermore, the capabilities of Nastran are extended such that design dependent loads can be applied, resulting in correct aeroelastic sensitivities of Nastran responses, making this framework suitable for optimization. The framework is verified against results from the commercial codes FAST and GH Bladed, using the NREL 61.5m rotor blade as a baseline for comparison, showing good agreement. Copyright (c) 2016 John Wiley & Sons, Ltd.