Cuprizone does not induce CNS demyelination in nonhuman primates

被引：9

作者：

Chen, Zhihong ^{[1
]}

Chen, Jacqueline T. ^{[1
]}

Johnson, Matthew ^{[1
]}

Gossman, Zachary C. ^{[1
]}

Hendrickson, Megan ^{[1
]}

Sakaie, Ken ^{[2
]}

Martinez-Rubio, Clarissa ^{[3
]}

Gale, John T. ^{[1
,4
]}

Trapp, Bruce D. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA

[2] Cleveland Clin, Neurol Inst, Cleveland, OH 44195 USA

[3] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

[4] Cleveland Clin, Neurol Inst, Ctr Neurol Restorat, Cleveland, OH 44195 USA

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2015年 / 2卷 / 02期

关键词：

COGNITIVE IMPAIRMENT; CORTICAL-LESIONS; MRI;

D O I：

10.1002/acn3.159

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has been shown to reliably induce brain demyelination in mice. To establish a nonhuman primate model of multiple sclerosis, young adult cynomolgus monkeys were administered cuprizone per os as a dietary supplement. The subjects received increasing cuprizone doses (0.3-3% of diet) for up to 18 weeks. Magnetic resonance imaging and immunohistological analyses did not reveal demyelination in these monkeys.

引用

页码：208 / 213

页数：6

共 20 条

[1] Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis [J].

Amato, M. P. ;

Portaccio, E. ;

Stromillo, M. L. ;

Goretti, B. ;

Zipoli, V. ;

Siracusa, G. ;

Battaglini, M. ;

Giorgio, A. ;

Bartolozzi, M. L. ;

Guidi, L. ;

Sorbi, S. ;

Federico, A. ;

De Stefano, N. .

NEUROLOGY, 2008, 71 (09) :632-638

[2]

Bates D, 2014, IME4 LINEAR MIXED EF

[3]

Calabrese M, 2009, ARCH NEUROL-CHICAGO, V66, P1144, DOI 10.1001/archneurol.2009.174

[4] Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4 [J].

Chen, Zhihong ;

Jalabi, Walid ;

Shpargel, Karl B. ;

Farabaugh, Kenneth T. ;

Dutta, Ranjan ;

Yin, Xinghua ;

Kidd, Grahame J. ;

Bergmann, Cornelia C. ;

Stohlman, Stephen A. ;

Trapp, Bruce D. .

JOURNAL OF NEUROSCIENCE, 2012, 32 (34) :11706-11715

[5] AUTOMATIC 3D INTERSUBJECT REGISTRATION OF MR VOLUMETRIC DATA IN STANDARDIZED TALAIRACH SPACE [J].

COLLINS, DL ;

NEELIN, P ;

PETERS, TM ;

EVANS, AC .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1994, 18 (02) :192-205

[6] Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis [J].

Deloire, MSA ;

Salort, E ;

Bonnet, M ;

Arimone, Y ;

Boudineau, M ;

Amieva, H ;

Barroso, B ;

Ouallet, JC ;

Pachai, C ;

Gailiaud, E ;

Petry, KG ;

Dousset, V ;

Fabrigoule, C ;

Brochet, B .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (04) :519-526

[7] Hippocampal Demyelination and Memory Dysfunction are Associated with Increased Levels of the Neuronal microRNA miR-124 and Reduced AMPA Receptors [J].

Dutta, Ranjan ;

Chomyk, Anthony M. ;

Chang, Ansi ;

Ribaudo, Michael V. ;

Deckard, Sadie A. ;

Doud, Mary K. ;

Edberg, Dale D. ;

Bai, Brian ;

Li, Michael ;

Baranzini, Sergio E. ;

Fox, Robert J. ;

Staugaitis, Susan M. ;

Macklin, Wendy B. ;

Trapp, Bruce D. .

ANNALS OF NEUROLOGY, 2013, 73 (05) :637-645

[8] Genomic Characterization of Japanese Macaque Rhadinovirus, a Novel Herpesvirus Isolated from a Nonhuman Primate with a Spontaneous Inflammatory Demyelinating Disease [J].

Estep, Ryan D. ;

Hansen, Scott G. ;

Rogers, Kelsey S. ;

Axthelm, Michael K. ;

Wong, Scott W. .

JOURNAL OF VIROLOGY, 2013, 87 (01) :512-523

[9] An MRI based average macaque monkey stereotaxic atlas and space (MNI monkey space) [J].

Frey, Stephen ;

Pandya, Deepak N. ;

Chakravarty, M. Mallar ;

Bailey, Lara ;

Petrides, Michael ;

Collins, D. Louis .

NEUROIMAGE, 2011, 55 (04) :1435-1442

[10] The cuprizone animal model: new insights into an old story [J].

Kipp, Markus ;

Clarner, Tim ;

Dang, Jon ;

Copray, Sjef ;

Beyer, Cordian .

ACTA NEUROPATHOLOGICA, 2009, 118 (06) :723-736

← 1 2 →