RETRACTED: CD133+/CD44+/Oct4+/Nestin+ stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic cancer (Retracted article. See vol. 120, pg. 302, 2018)

被引：31

作者：

Wang, Dongqing ^{[1
]}

Zhu, Haitao ^{[1
]}

Zhu, Ying ^{[1
]}

Liu, Yanfang ^{[2
]}

Shen, Huiling ^{[2
]}

Yin, Ruigen ^{[1
]}

Zhang, Zhijian ^{[3
]}

Su, Zhaoliang ^{[3
]}

机构：

[1] Jiangsu Univ, Affiliated Hosp, Zhenjiang 212001, Peoples R China

[2] Jiangsu Univ, Affiliated Peoples Hosp, Zhenjiang 212008, Peoples R China

[3] Jiangsu Univ, Dept & Lab Immunol, Zhenjiang 212008, Peoples R China

来源：

ACTA HISTOCHEMICA | 2013年 / 115卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer stem cell; Panc-1; MDR1; Drug-resistance; CLINICAL BENEFIT; GEMCITABINE; IDENTIFICATION; GLIOBLASTOMA; THERAPY; POPULATION; CARCINOMA; EXPANSION;

D O I：

10.1016/j.acthis.2012.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pancreatic cancer is an aggressive malignant disease. Owing to the lack of early symptoms, accompanied by extensive metastasis and high resistance to chemotherapy, pancreatic adenocarcinoma becomes the fourth leading cause of cancer-related deaths. In this study, we identified a subpopulation of cells isolated from the Panc-1 cell line and named pancreatic cancer stem-like cells. These Panc-1 stem-like cells expressed high levels of CD133/CD44/Oct4/Nestin. Compared to Panc-1 cells, Panc-1 stem-like cells were resistant to gemcitabine and expressed high levels of MDR1; furthermore, Panc-1 stem-like cells have high anti-apoptotic, but weak proliferative potential. These results indicated that Panc-1 stem-like cells, as a novel group, may be a potential major cause of pancreatic cancer multidrug resistance and extensive metastasis. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：349 / 356

页数：8

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