H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes

被引：194
作者：
Ha, Y
Stevens, DJ
Skehel, JJ
Wiley, DC
机构：
[1] Natl Inst Med Res, London NW7 1AA, England
[2] Howard Hughes Med Inst, Coconut Grove, FL 33133 USA
[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
来源：
EMBO JOURNAL | 2002年 / 21卷 / 05期
基金：
英国惠康基金;
关键词：
avian influenza; influenza A virus; sialic acid; swine influenza; virus evolution;
D O I：
10.1093/emboj/21.5.865
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the RA-esterase-fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
引用
收藏
页码：865 / 875
页数：11
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