Preparation of Recombinant Atoxic Form of Exotoxin A from Pseudomonas Aeruginosa

被引：2

作者：

Kaloshin, A. A. ^{[1
]}

Isakov, M. A. ^{[1
]}

Mikhailova, N. A. ^{[1
]}

Vertiev, Ju. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, II Mechnikov Inst Vaccines & Sera, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 154卷 / 03期

关键词：

Pseudomonas aeruginosa; exotoxin A; antitoxin; toxA gene; MECHANISM;

D O I：

10.1007/s10517-013-1947-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Nucleotide sequences encoding full-length protein of Pseudomonas aeruginosa exotoxin A and its atoxic form were cloned and expressed in Escherichia coli cells. Purified recombinant exotoxin and immune rabbit sera protected mice from exotoxin A.

引用

页码：346 / 350

页数：5

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