The effect of miRNA and autophagy on colorectal cancer

被引：63

作者：

Long, Jiali ^{[1
,2
]}

He, Qinglian ^{[1
]}

Yin, Yuting ^{[1
]}

Lei, Xue ^{[1
]}

Li, Ziqi ^{[1
]}

Zhu, Wei ^{[1
]}

机构：

[1] Guangdong Med Univ, Dept Pathol, 1 Xincheng Rd, Dongguan 523808, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Pathol, Shenzhen, Peoples R China

来源：

CELL PROLIFERATION | 2020年 / 53卷 / 10期

基金：

中国国家自然科学基金;

关键词：

autophagy; colorectal cancer; microRNA; therapy; CONFERS 5-FLUOROURACIL RESISTANCE; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; COLON-CANCER; STEM-CELLS; REGULATES AUTOPHAGY; INHIBIT AUTOPHAGY; MAMMALIAN TARGET; EPITHELIAL-CELLS; DRUG-RESISTANCE;

D O I：

10.1111/cpr.12900

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Colorectal cancer (CRC) has become a concern because of its high recurrence rate and metastasis rate, low early diagnosis rate and poor therapeutic effect. At present, various studies have shown that autophagy is closely connected with the occurrence and progression of CRC. Autophagy is a highly cytosolic catabolic process involved in lysosomes in biological evolution. Cells degrade proteins and damaged organelles by autophagy to achieve material circulation and maintain cell homeostasis. Moreover, microRNAs are key regulators of autophagy, and their mediated regulation of transcriptional and post-transcriptional levels plays an important role in autophagy in CRC cells. This review focuses on the recent research advances of how autophagy and related microRNAs are involved in affecting occurrence and progression of CRC and provides a new perspective for the study of CRC treatment strategies.

引用

页数：10

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