Association of polymorphisms in the LRP1 and A2M genes with Alzheimer's disease in the Northern Chinese Han population

被引:8
作者
Yuan, Quan
Wang, Fen
Xue, Sufang
Jia, Jianping [1 ]
机构
[1] Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; A2M; LRP1; Polymorphism; RECEPTOR-RELATED PROTEIN; APOLIPOPROTEIN-E RECEPTOR; BETA-AMYLOID PEPTIDE; ALPHA(2)-MACROGLOBULIN RECEPTOR; RISK; ALPHA-2-MACROGLOBULIN;
D O I
10.1016/j.jocn.2012.01.052
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Low-density lipoprotein receptor-related protein1 (LRP1) and alpha-2-macroglobulin (A2M) are candidate genes for sporadic Alzheimer's disease (SAD). It is not clear whether the LRP1 exon 3 and A2M exon 24 polymorphisms are associated with SAD. In the present study, we used direct sequencing to genotype the LRP1 C766T (rs1799986) polymorphism in exon 3 and the A2M I1000V (rs669) polymorphism in exon 24 in 364 patients with SAD and 291 healthy control subjects from the Northern Chinese Han population. The distributions of LRP1 genotypes (chi-squared [chi(2)] = 7.25, degrees of freedom [d.f.] = 2, p = 0.027) and alleles (chi(2) = 8.154, d.f. = 1, p = 0.004) were significantly different between patients and controls who were apolipoprotein E (APOE) epsilon 4 positive. The T allele and TT+TC genotype were associated with a reduced risk of developing SAD (T allele: odds ratio [OR] = 0.541, 95% confidence interval [CI] = 0.368-0.859, p = 0.005; TT+TC genotype: OR = 0.613,95% CI = 0.315-0.725, p = 0.012). There was no statistically significant difference in allele and genotype frequencies between patients with SAD and control subjects for the A2M I1000V polymorphism, even after stratification by age of onset, gender, and APOE epsilon 4 status. We found an interaction between LRP1 and APOE genotypes (p = 0.001), but no interaction between LRP1 and A2M genotypes. Our results suggest that the T allele of the LRP1 C766T polymorphism is associated with a decreased risk of SAD in APOE epsilon 4 carriers from the Northern Han Chinese population. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:247 / 250
页数:4
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