MiRNA-21 has effects to protect kidney injury induced by sepsis

被引：39

作者：

Fu Dian ^{[1
]}

Dong Jie ^{[1
]}

Li Ping ^{[1
]}

Tang Chaopeng ^{[1
]}

Cheng Wen ^{[1
]}

Xu Zhenyu ^{[1
]}

Zhou Wenquan ^{[1
]}

Ge Jingping ^{[1
]}

Xia Chen ^{[2
]}

Zhang Zhengyu ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Nanjing Jinling Hosp, Dept Urol, Nanjing 210002, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Childrens Hosp, Nanjing 210000, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 94卷

关键词：

miRNA-21; Vitro; Vovo; Apoptosis; PTEN; PI3K; AKT; Kidney injury; SIGNALING PATHWAY; APOPTOSIS; MICRORNA-21; MIR-21; CANCER; CELLS; REPERFUSION; EXPRESSION; MECHANISM; TARGETS;

D O I：

10.1016/j.biopha.2017.07.098

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To investigate the miRNA-21 over-expression in the acute kidney injury induced by sepsis, we developed a sepsis induced in vitro model by lip polysaccharide (LPS) and in vovo model by cecal ligation and puncture (CLP) surgery. LPS or CLP surgery induced kidney cell apoptosis increasing. However, the kidney injury indexes of miRNA groups which were transfected with miRNA-21 were significantly suppressed. In further study, the relative proteins expressions were evaluated to explain the miRNA-21 mechanism to improve sepsis induced kidney cell apoptosis. The results were shown that miRNA-21 over-expression had effects to protect kidney cell apoptosis induced by sepsis via PTEN/PI3K/AKT signaling pathway. (C) 2017 Published by Elsevier Masson SAS.

引用

页码：1138 / 1144

页数：7

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