Exploring the endocrine manifestations of DICER1 mutations

被引：21

作者：

Choong, Catherine S. ^{[3
,4
]}

Priest, John R. ^{[8
,9
]}

Foulkes, William D. ^{[1
,2
,5
,6
,7
]}

机构：

[1] McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ H2W 1S6, Canada

[2] McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ H2W 1S6, Canada

[3] Univ Western Australia, Sch Paediat & Child Hlth, Subiaco, WA 6008, Australia

[4] Princess Margaret Hosp Children, Dept Endocrinol, Subiaco, WA 6008, Australia

[5] McGill Univ, Jewish Gen Hosp, Dept Med Genet, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[6] McGill Univ, Jewish Gen Hosp, Segal Canc Ctr, Lady Davis Inst, Montreal, PQ H3T 1E2, Canada

[7] McGill Univ, Ctr Hlth, Dept Med Genet & Res Inst, Montreal, PQ H3G 1A4, Canada

[8] Childrens Hosp, Int Pleuropulmonary Blastoma Registry, Minneapolis, MN 55404 USA

[9] Clin Minnesota, Minneapolis, MN 55404 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 09期

关键词：

D O I：

10.1016/j.molmed.2012.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of each new cancer susceptibility gene answers one set of questions but poses many more. In this article, we outline a recent example: a new cancer syndrome caused by germline mutations in DICER1, responsible for microRNA processing. In particular, we discuss the endocrine manifestations of mutations in this crucial gene.

引用

页码：503 / 505

页数：3

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