The pathogenesis of systemic lupus erythematosus-an update

被引：268

作者：

Choi, Jinyoung ^{[1
]}

Kim, Sang Taek ^{[1
]}

Craft, Joe ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med Rheumatol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 06期

关键词：

HELPER T-CELLS; B-LYMPHOCYTE STIMULATOR; SHORT-LIVED PLASMABLASTS; MONOCLONAL-ANTIBODY; INTERFERON-ALPHA; DISEASE-ACTIVITY; DENDRITIC CELLS; MURINE LUPUS; I INTERFERON; DOUBLE-BLIND;

D O I：

10.1016/j.coi.2012.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

引用

页码：651 / 657

页数：7

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