The pharmacology of curcumin: is it the degradation products?

被引：239

作者：

Shen, Liang ^{[1
]}

Ji, Hong-Fang ^{[1
]}

机构：

[1] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

curcumin; degradation products; pharmacology; vanillin; ferulic acid; Alzheimer's disease; CHEMOPREVENTIVE AGENT CURCUMIN; NF-KAPPA-B; I CLINICAL-TRIAL; FERULIC ACID; ALZHEIMERS-DISEASE; PHENOLIC-ACIDS; CANCER-CELLS; ANTIOXIDANT; INHIBITION; METABOLITES;

D O I：

10.1016/j.molmed.2012.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural product curcumin has gained considerable attention in recent years for its multiple pharmacological activities, but more efforts are needed to understand how curcumin can have these pharmacological effects considering its low bioavailability. In addition, it is unclear how curcumin exerts inhibitory effects against numerous enzymes, especially those that cannot accommodate curcumin within recognized binding pockets. By analyzing the similarities between the biological activities of curcumin and its degradation products against diseases such as Alzheimer's disease and cancer, as well as the preferential inhibition of some enzymes by degradation products, it appears that the bioactive degradation products may contribute to the pharmacological effects of curcumin. This possibility should be given full attention when elucidating the pharmacology of this promising natural product for various diseases.

引用

页码：138 / 144

页数：7

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