Activity-based fluorescent probes for monitoring sulfatase activity

被引：12
|
作者：
Park, Hyun-Joo [1 ]
Rhee, Hyun-Woo [1 ]
Hong, Jong-In [1 ]
机构：
[1] Seoul Natl Univ, Dept Chem, Coll Nat Sci, Seoul 151747, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 15期
关键词：
Activity-based probe; Fluorescence; Sulfatase; BREAST-CANCER; STEROID SULFATASE; RECOGNITION; INHIBITION; MECHANISM; TOOLS;
D O I：
10.1016/j.bmcl.2012.06.045
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A small-molecule probe for sulfatase is developed that shows a significant change in fluorescence upon reaction with sulfatase in an activity-based manner. As this probe is free from interference from background fluorescence caused by an unreacted probe, it could be a simple and efficient tool for the study of sulfatase activity. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4939 / 4941
页数：3
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