Activity-based fluorescent probes for monitoring sulfatase activity

被引：12

作者：

Park, Hyun-Joo ^{[1
]}

Rhee, Hyun-Woo ^{[1
]}

Hong, Jong-In ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Coll Nat Sci, Seoul 151747, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 15期

关键词：

Activity-based probe; Fluorescence; Sulfatase; BREAST-CANCER; STEROID SULFATASE; RECOGNITION; INHIBITION; MECHANISM; TOOLS;

D O I：

10.1016/j.bmcl.2012.06.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A small-molecule probe for sulfatase is developed that shows a significant change in fluorescence upon reaction with sulfatase in an activity-based manner. As this probe is free from interference from background fluorescence caused by an unreacted probe, it could be a simple and efficient tool for the study of sulfatase activity. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4939 / 4941

页数：3

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