Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress

被引：13
作者：
Stvolinsky, S. [1 ]
Toropova, K. [2 ]
Gordeeva, M. [2 ]
Kazey, V. [3 ]
Sato, T. [4 ]
Meguro, K. [4 ]
Boldyrev, A. [1 ,2 ]
机构：
[1] Res Ctr Neurol, Moscow 123367, Russia
[2] Moscow MV Lomonosov State Univ, Moscow 119992, Russia
[3] Chem Divers Res Inst, Chimki 141400, Moscow Region, Russia
[4] Hamari Chem Ltd, Higashi Yodogawa Ku, Osaka 5330024, Japan
来源：
AMINO ACIDS | 2012年 / 43卷 / 01期
关键词：
Carnosine; Trolox (TM); Acute hypobaric hypoxia; Oxidative stress; Brain; Antioxidant defense; DROSOPHILA-MELANOGASTER; ANTIOXIDANT ACTIVITY; LIFE-SPAN; ENDOGENOUS NEUROPROTECTOR; CEREBRAL-ISCHEMIA; HOMOCARNOSINE; TROLOX; BRAIN; RATS; ANSERINE;
D O I：
10.1007/s00726-012-1256-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The novel synthetic derivative of carnosine, (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbonyl-beta-alanyl-l-histidine (S-Trolox (TM)-Carnosine, STC) increases the resistance of rats to experimental acute hypobaric hypoxia (AHH) thus protecting brain from the oxidative damage. This effect is accompanied by better preservation of the acquired skills in Morris water maze possibly by increasing efficiency of the brain antioxidant system. In addition, STC caused an increase in life span of both male and female fruit fly Drosophila melanogaster whereas carnosine increased life span only in male fruit flies. The results indicate that development of the drug based on STC could be beneficial in neurology and gerontology.
引用
收藏
页码：165 / 170
页数：6
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