Alzheimer disease: Mechanistic understanding predicts novel therapies

被引：333

作者：

Selkoe, DJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2004年 / 140卷 / 08期

关键词：

D O I：

10.7326/0003-4819-140-8-200404200-00047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the last several years, Alzheimer disease researchers have come to agree that certain biochemical changes in the hippocampus and association cortices occur many years or decades before clinical symptoms. We can now describe a rough outline of the cascade of events leading to disease.

引用

页码：627 / 638

页数：12

共 93 条

[1] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[2] Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease [J].

Bales, KR ;

Verina, T ;

Cummins, DJ ;

Du, YS ;

Dodel, TC ;

Saura, J ;

Fishman, CE ;

DeLong, CA ;

Piccardo, P ;

Petegnief, V ;

Ghetti, B ;

Paul, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15233-15238

[3] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].

Bard, F ;

Cannon, C ;

Barbour, R ;

Burke, RL ;

Games, D ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Lieberburg, I ;

Motter, R ;

Nguyen, M ;

Soriano, F ;

Vasquez, N ;

Weiss, K ;

Welch, B ;

Seubert, P ;

Schenk, D ;

Yednock, T .

NATURE MEDICINE, 2000, 6 (08) :916-919

[4] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J].

BEHL, C ;

DAVIS, JB ;

LESLEY, R ;

SCHUBERT, D .

CELL, 1994, 77 (06) :817-827

[5] Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent γ-secretase cleavage [J].

Berezovska, O ;

Jack, C ;

Deng, A ;

Gastineau, N ;

Rebeck, GW ;

Hyman, BT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) :30018-30023

[6] BACE1 is the major β-secretase for generation of Aβ peptides by neurons [J].

Cai, HB ;

Wang, YS ;

McCarthy, D ;

Wen, HJ ;

Borchelt, DR ;

Price, DL ;

Wong, PC .

NATURE NEUROSCIENCE, 2001, 4 (03) :233-234

[7] A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60 [J].

Cao, XW ;

Südhof, TC .

SCIENCE, 2001, 293 (5527) :115-120

[8] Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice [J].

Cherny, RA ;

Atwood, CS ;

Xilinas, ME ;

Gray, DN ;

Jones, WD ;

McLean, CA ;

Barnham, KJ ;

Volitakis, I ;

Fraser, FW ;

Kim, YS ;

Huang, XD ;

Goldstein, LE ;

Moir, RD ;

Lim, JT ;

Beyreuther, K ;

Zheng, H ;

Tanzi, RE ;

Masters, CL ;

Bush, AI .

NEURON, 2001, 30 (03) :665-676

[9] beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease [J].

Cummings, BJ ;

Pike, CJ ;

Shankle, R ;

Cotman, CW .

NEUROBIOLOGY OF AGING, 1996, 17 (06) :921-933

[10] A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].

De Strooper, B ;

Annaert, W ;

Cupers, P ;

Saftig, P ;

Craessaerts, K ;

Mumm, JS ;

Schroeter, EH ;

Schrijvers, V ;

Wolfe, MS ;

Ray, WJ ;

Goate, A ;

Kopan, R .

NATURE, 1999, 398 (6727) :518-522

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