Indole Synthesis by Rhodium(III)-Catalyzed Hydrazine-Directed C-H Activation: Redox-Neutral and Traceless by N-N Bond Cleavage

被引：322
作者：
Zhao, Dongbing [1 ]
Shi, Zhuangzhi [1 ]
Glorius, Frank [1 ]
机构：
[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 47期
基金：
欧洲研究理事会;
关键词：
CH activation; heteroarenes; indoles; oxidizing directing groups; rhodium catalysis; ISOQUINOLONE SYNTHESIS; OXIDATIVE CYCLIZATION; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; ARYL ENAMINES; O BOND; FUNCTIONALIZATION; ALKALOIDS; ARYLATION; ANNULATION;
D O I：
10.1002/anie.201306098
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a RhIII-catalyzed directed C-H activation step and a successive coupling with alkynes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12426 / 12429
页数：4
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