Preventing the binding of pathogens to the host by controlling sphingolipid metabolism

被引：16

作者：

Radin, Norman S. ^{[1
]}

机构：

[1] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 03期

关键词：

glycolipid depletion therapy; pathogen binding to decoys; protective adhesin therapy; receptors and ligands; HIV-1;

D O I：

10.1016/j.micinf.2005.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The binding of many pathogens and toxins to human cells can be inhibited by (1) depleting host cells of their surface glycosphingolipids; (2) coating the binding sites on pathogens (adhesins) with glycosphingolipid-like substances (decoys); (3) coating the host's glycosphingolipids with substances that compete with the pathogen for binding. Details of using these methods are described. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：938 / 945

页数：8

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