Impairment of inhibition of unattended stimuli in schizophrenic patients: Event-related potential correlates during selective attention

被引：13

作者：

Iwanami, A ^{[1
]}

Kanamori, R ^{[1
]}

Isono, H ^{[1
]}

Okajima, Y ^{[1
]}

Kamijima, K ^{[1
]}

机构：

[1] DOKKYO UNIV,SCH MED,DEPT NEUROPSYCHIAT,TOKYO,JAPAN

来源：

NEUROPSYCHOBIOLOGY | 1996年 / 34卷 / 02期

关键词：

schizophrenia; event-related potential; P300; selective attention; inhibition; dichotic listening;

D O I：

10.1159/000119292

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Auditory event-related potentials (ERPs) were recorded during a dichotic listening task in 18 remitted schizophrenic patients and in 18 age-matched controls. The subjects were instructed to press a button in response to the target tones applied to one designated ear. In schizophrenic patients, P300 amplitude for attended target was significantly smaller than in controls. Schizophrenic patients also exhibited reduced positive potentials between 200 and 400 ms in ERPs for unattended nontarget. These results suggested that schizophrenic patients lack the ability to inhibit unattended or irrelevant stimuli, in addition to impairment of 'context closure' in the information processing.

引用

页码：57 / 62

页数：6

共 29 条

[1] BRAIN MECHANISM OF SELECTIVE LISTENING REFLECTED BY EVENT-RELATED POTENTIALS [J].