Efficacy of an intranasal modified live bovine respiratory syncytial virus and temperature-sensitive parainfluenza type 3 virus vaccine in 3-week-old calves experimentally challenged with PI3V

被引：21

作者：

Vangeel, Ilse ^{[1
]}

Ioannou, Faye ^{[1
]}

Riegler, Lutz ^{[1
]}

Salt, Jeremy S. ^{[1
]}

Harmeyer, Silke S. ^{[1
]}

机构：

[1] Pfizer Anim Hlth, Vet Med Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

VETERINARY JOURNAL | 2009年 / 179卷 / 01期

关键词：

Bovine respiratory disease; Parainfluenza type 3 virus; Vaccine efficacy; Intranasal vaccination; CELL-MEDIATED-IMMUNITY; PARA-INFLUENZA-3; VIRUS; DISEASE; CATTLE; RESISTANCE; PNEUMONIA;

D O I：

10.1016/j.tvjl.2007.08.008

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Two experimental parainfluenza type 3 virus (PI3V) challenge studies were undertaken to evaluate the efficacy of a single intranasal dose of an attenuated live vaccine containing modified live bovine respiratory syncytial Virus (BRSV) and temperature-sensitive PI3V in 3-week-old calves. In the first study, vaccine efficacy was evaluated in colostrum deprived calves. Nasal shedding of PI3V was highly significantly reduced in vaccinated calves challenged 10 days or 21 days after vaccination. In the second Study, vaccine efficacy was assessed in calves with maternal antibodies against PI3V by challenge 66 days post-vaccination. Vaccination also significantly reduced PI3V excretion after challenge in this study. In both studies, clinical signs after challenge were very mild and were not different between vaccinated and control calves. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：101 / 108

页数：8

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