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Synthesis and spectroscopic characterization of 3,4-difluoroacetophenone-thiosemicarbazone and its palladium(II) complex: Evaluation of antimicrobial and antitumour activity
被引:31
作者:
Jagadeesh, M.
[1
]
Rashmi, H. K.
[2
]
Rao, Y. Subba
[3
]
Reddy, A. Sreenath
[1
]
Prathima, B.
[1
]
Devi, P. Uma Maheswari
[2
]
Reddy, A. Varada
[1
]
机构:
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Sri Padmayati MahilaVisyaVidyalayam, Dept Appl Microbiol, Tirupati 517502, Andhra Pradesh, India
[3] Sri Venkateswara Univ, DST PURSE Ctr, Tirupati 517502, Andhra Pradesh, India
关键词:
Fluoro substituted thiosemicarbazone;
Pd(II) complex;
Raman spectra and Infrared spectroscopy;
SCHIFF-BASE LIGANDS;
PD-II COMPLEXES;
NICKEL-COMPLEX;
THIOSEMICARBAZONES;
DERIVATIVES;
DESIGN;
DNA;
D O I:
10.1016/j.saa.2013.06.071
中图分类号:
O433 [光谱学];
学科分类号:
0703 ;
070302 ;
摘要:
A new cis-palladium(II)diaqua(3,4-difluoroacetophenonethiosemicarbazone complex (Pd(II) complex) is synthesized using 3,4-difluoroacetophenonethiosemicarbazone(L). The L and its Pd(II) complex are characterized and confirmed by elemental analyses, electrochemical analyses, FT-IR, FT-Raman, UV-Vis, HRMS and LC-MS techniques. Ligand L is further characterized by H-1, C-13 and F-19 NMR spectroscopy. The crystal structure of L is unambiguously characterized by single X-ray crystallography. The ligand (L) belongs to monoclinic system with P2(1)/C space group and the unit cell parameters are a(angstrom) = 9.1144(7), b(angstrom) = 13.7928(7), c(angstrom) = 8.4174(5), alpha(degrees)= 90, beta(degrees) = 100.715, gamma(degrees) = 90 and volume V(A(3))= 1039.73(11). The Raman bands observed for the L and its Pd(II) complex are in good agreement with the FT-IR spectral data. The Pd(II) complex is found to be highly efficient in inhibiting the growth of human pathogens like Salmonella typhimurium and Klebsiella pneumonia with MIC value 10.0 mu g/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized compounds have shown antiproliferative activity against the human breast cancer cell lines MDA-MB231 by intermitting the regular pathway of ribonucleotidereductase. (C) 2013 Elsevier B.V. All rights reserved.
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页码:583 / 587
页数:5
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