Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer

被引：8
作者：
Yaren, Arzu [1 ]
Turgut, Sebahat [2 ]
Ayada, Ceylan [2 ]
Akcilar, Raziye [2 ]
Degirmencioglu, Serkan [1 ]
Dogu, Gamze Gokoz [1 ]
机构：
[1] Pamukkale Univ, Fac Med, Dept Med Oncol, Denizli, Turkey
[2] Pamukkale Univ, Fac Med, Dept Physiol, Denizli, Turkey
来源：
GENE | 2012年 / 503卷 / 02期
关键词：
Insulin-like growth factor; Gene polymorphism; Breast cancer; Prognosis; LIFE-STYLE FACTORS; PROSTATE-CANCER; RISK; REPEAT; PROGNOSIS; WOMEN; GENOTYPE; SEQUENCE; IGFBP-3;
D O I：
10.1016/j.gene.2012.04.078
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：244 / 247
页数：4
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