CT screening for lung cancer - Significance of diagnoses in its baseline cycle

被引:41
作者
Henschke, CI
Shaham, D
Yankelevitz, DF
Kramer, A
Kostis, WJ
Reeves, AP
Vazquez, M
Koizumi, J
Miettinen, OS
机构
[1] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY 10021 USA
[2] Hadassah Med Ctr, Dept Radiol, IL-91120 Jerusalem, Israel
[3] Cornell Univ, Sch Engn & Comp Sci, Ithaca, NY 14853 USA
[4] Cornell Univ, Weill Med Coll, Dept Pathol, Ithaca, NY 14853 USA
[5] Cornell Univ, Weill Med Coll, Dept Med, Ithaca, NY 14853 USA
[6] McGill Univ, Fac Med, Dept Epidemiol & Biostat, Montreal, PQ H3A 2T5, Canada
[7] McGill Univ, Fac Med, Dept Med, Montreal, PQ H3A 2T5, Canada
关键词
lung cancer; screening; overdiagnosis; tumor doubling;
D O I
10.1016/j.clinimag.2005.07.003
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: The aim of this study was to assess the significance of Stage I diagnoses of lung cancer in the baseline cycle of screening for this disease, with special reference to the potential for overdiagnosis. Methods: We reviewed all 69 cases of Stage I lung cancer diagnosis resulting from our baseline CT screening. Among these 69 cases of lung cancer, 24 presented as solid, 30 as part-solid, and 15 as nonsolid nodules. The extent to which these represented genuine malignancy was assessed by a panel of experts on lung pathology, and the "aggressiveness" of these cases was addressed by the criterion of the tumor's volume doubling time being less than 400 days. Results: The expert panel confirmed all 69 cases as representing genuine malignancy. Among the 69 cases without evidence of metastases, the proportion that satisfied the aggressiveness criterion was 60/69=87%. The corresponding proportions by presentation as solid, part-solid, and nonsolid nodule were 23/24 (96%), 27/30 (90%), and 10/15 (67%), respectively. Conclusions: In baseline CT screening for lung cancer, overdiagnosis of the disease is uncommon, with cases presenting as a nonsolid nodule a possible exception to this. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 15
页数:5
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