Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice

被引:11
作者
Akimoto, Takayuki [1 ]
Okuhira, Kanako [2 ]
Aizawa, Katsuji [1 ]
Wada, Shogo [1 ]
Honda, Hiroaki [3 ]
Fukubayashi, Toru [2 ]
Ushida, Takashi [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Div Regenerat Med Engn,Bunkyo Ku, Tokyo 1130033, Japan
[2] Waseda Univ, Fac Sports Sci, Tokorozawa, Saitama, Japan
[3] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Dis Model, Hiroshima, Japan
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2013年 / 304卷 / 06期
关键词
mechanotransduction; p38; MAPK; peroxisome proliferator-activated receptor-gamma coactivator-1 alpha muscle fiber type; JUN NH2-TERMINAL KINASE; P38; PGC-1-ALPHA; EXERCISE; COACTIVATOR; ACTIVATION; INCREASES; EXPRESSION; DEFICIENT; INDUCTION;
D O I
10.1152/ajpcell.00243.2012
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Ushida T. Skeletal muscle adaptation in response to mechanical stress in p130cas(-/-) mice. Am J Physiol Cell Physiol 304: C541-C547, 2013. First published January 16, 2013; doi: 10.1152/ajpcell.00243.2012.-Mammalian skeletal muscles undergo adaptation in response to changes in the functional demands upon them, involving mechanical-stress-induced cellular signaling called "mechanotransduction." We hypothesized that p130Cas, which is reported to act as a mechanosensor that transduces mechanical extension into cellular signaling, plays an important role in maintaining and promoting skeletal muscle adaptation in response to mechanical stress via the p38 MAPK signaling pathway. We demonstrate that muscle-specific p130Cas(-/-) mice express the contractile proteins normally in skeletal muscle. Furthermore, muscle-specific p130Cas(-/-) mice show normal mechanical-stress-induced muscle adaptation, including exercise-induced IIb-to-IIa muscle fiber type transformation and hypertrophy. Finally, we provide evidence that exercise-induced p38 MAPK signaling is not impaired by the muscle-specific deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
引用
收藏
页码:C541 / C547
页数:7
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