The trabecular meshwork: Structure, function and clinical implications. A review of the literature

被引：73

作者：

Buffault, J. ^{[1
]}

Labb, A. ^{[1
,2
,3
,4
]}

Hamard, P. ^{[1
]}

Brignole-Baudouin, F. ^{[4
,5
]}

Baudouin, C. ^{[1
,2
,3
,4
]}

机构：

[1] Ctr Hosp Natl Ophtalmol Quinze Vingts, IHU FOReSIGHT, Ophthalmol Dept, 28 Rue Charenton, F-75012 Paris, France

[2] Hop Ambroise Pare, AP HP, Ophthalmol Dept, IHU FOReSIGHT, 9 Ave Charles De Gaulle, F-92100 Boulogne, France

[3] Univ Versailles St Quentin En Yvelines, F-78000 Versailles, France

[4] Sorbonne Univ, Inst Vis, INSERM, CNRS, 17 Rue Moreau, F-75012 Paris, France

[5] Ctr Hosp Natl Ophtalmol Quinze Vingts, IHU FOReSIGHT, Lab Dept, 28 Rue Charenton, F-75012 Paris, France

来源：

JOURNAL FRANCAIS D OPHTALMOLOGIE | 2020年 / 43卷 / 07期

关键词：

Trabecular meshwork; Glaucoma; Intraocutar pressure; Ocular hypertension; Iridocorneat angle; Trabecutar meshwork cells; Aqueous humor; Primary open angle glaucoma; Secondary glaucoma; Steroid-induced glaucoma; Pigmentary glaucoma; Pseudoexfoliative glaucoma; Glaucoma medications; Trabeculoplasty; Glaucoma surgery; AQUEOUS-HUMOR OUTFLOW; OCULAR HYPERTENSION TREATMENT; OPEN-ANGLE GLAUCOMA; INTRAOCULAR-PRESSURE; EXTRACELLULAR-MATRIX; IN-VITRO; STEM-CELLS; SIGNALING PATHWAYS; ANTIGLAUCOMA DRUGS; RANDOMIZED-TRIAL;

D O I：

10.1016/j.jfo.2020.05.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, three-dimensional structure composed of trabecular meshwork cells (TMC) interdigitated into a muttilayered organization within the extracetlutar matrix (ECM). The purpose of this literature review is to provide an overview of current understanding of the trabecular meshwork and its pathophysiology in glaucoma. Thus, we will present the main anatomical and cellular bases for the regulation of aqueous humor outflow resistance, the pathophysiological mechanisms involved in trabecular dysfunction in the various types of glaucoma, as well as current and future therapeutic strategies targeting the trabecular meshwork. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页码：E217 / E230

页数：14

共 124 条

[1] A new insight into the cellular regulation of aqueous outflow: how trabecular meshwork endothelial cells drive a mechanism that regulates the permeability of Schlemm's canal endothelial cells [J].