Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key

被引：144

作者：

Castrogiovanni, Paola ^{[1
]}

Di Rosa, Michelino ^{[1
]}

Ravalli, Silvia ^{[1
]}

Castorina, Alessandro ^{[2
,3
]}

Guglielmino, Claudia ^{[1
]}

Imbesi, Rosa ^{[1
]}

Vecchio, Michele ^{[4
]}

Drago, Filippo ^{[4
]}

Szychlinska, Marta Anna ^{[1
]}

Musumeci, Giuseppe ^{[1
,5
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, Sch Med, Via S Sofia 87, I-95124 Catania, Italy

[2] Univ Technol Sydney, Sch Life Sci, Fac Sci, POB 123, Sydney, NSW 2007, Australia

[3] Univ Sydney, Discipline Anat & Histol, Sch Med Sci, Sydney, NSW 2006, Australia

[4] Univ Catania, Dept Biomed & Biotechnol Sci, Pharmacol Sect, Via S Sofia 67, I-95123 Catania, Italy

[5] Italian Natl Olymp Comm CONI Sicily, Sch Sport, Via Emanuele Notarbartolo, I-90141 Palermo, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 03期

关键词：

osteoarthritis; synovium; physical activity; interleukins; lubricin; IN-VITRO; CARTILAGE DEGENERATION; 3-DIMENSIONAL ULTRASTRUCTURE; ARTICULAR-CARTILAGE; SYNOVIAL-FLUID; LUBRICIN; JOINT; EXERCISE; MODEL; BIOSYNTHESIS;

D O I：

10.3390/ijms20030511

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1, IL-6, TNF-, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.

引用

页数：17

共 54 条

[31] Lubricin expression in human osteoarthritic knee meniscus and synovial fluid: A morphological, immunohistochemical and biochemical study [J].