Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

被引：56

作者：

Domino, Edward F. ^{[1
]}

Luby, Elliot D. ^{[2
,3
]}

机构：

[1] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA

[2] Wayne State Univ, Dept Psychiat & Behav Sci, Detroit, MI USA

[3] Comprehens Psychiat Serv, Farmington Hills, MI USA

来源：

SCHIZOPHRENIA BULLETIN | 2012年 / 38卷 / 05期

关键词：

phencyclidine; drug model; drug of abuse; MESSENGER-RNA EXPRESSION; PREFRONTAL CORTEX; RECEPTOR-BINDING; DOPAMINE HYPOTHESIS; THOUGHT-DISORDER; NMDA ANTAGONIST; SCHIZOPHRENIA; PHENCYCLIDINE; KETAMINE; NEURONS;

D O I：

10.1093/schbul/sbs011

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.

引用

页码：914 / 919

页数：6

共 44 条

[1] The NMDA antagonist model for schizophrenia: Promise and pitfalls [J].

Abi-Saab, WM ;

D'Souza, DC ;

Moghaddam, B ;

Krystal, JH .

PHARMACOPSYCHIATRY, 1998, 31 :104-109

[2] Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia [J].

Adler, CM ;

Malhotra, AK ;

Elman, I ;

Goldberg, T ;

Egan, M ;

Pickar, D ;

Breier, A .

AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (10) :1646-1649

[3] Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia [J].

Avila, MT ;

Weiler, MA ;

Lahti, AC ;

Tamminga, CA ;

Thaker, GK .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (09) :1490-1496

[4] Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia:: A 123I-Iomazenil SPET study [J].

Ball, S ;

Busatto, GF ;

David, AS ;

Jones, SH ;

Hemsley, DR ;

Pilowsky, LS ;

Costa, DC ;

Ell, PJ ;

Kerwin, RW .

BIOLOGICAL PSYCHIATRY, 1998, 43 (02) :107-117

[5] Up-regulation of GABA(A) receptor binding on neurons of the prefrontal cortex in schizophrenic subjects [J].

Benes, FM ;

Vincent, SL ;

Marie, A ;

Khan, Y .

NEUROSCIENCE, 1996, 75 (04) :1021-1031

[6] GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder [J].

Benes, FM ;

Berretta, S .

NEUROPSYCHOPHARMACOLOGY, 2001, 25 (01) :1-27

[7] Emerging principles of altered neural circuitry in schizophrenia [J].

Benes, FM .

BRAIN RESEARCH REVIEWS, 2000, 31 (2-3) :251-269

[8]

Busatto GF, 1997, AM J PSYCHIAT, V154, P56

[9] GABAA receptors and their associated proteins: Implications in the etiology and treatment of schizophrenia and related disorders [J].

Charych, Erik I. ;

Liu, Feng ;

Moss, Stephen J. ;

Brandon, Nicholas J. .

NEUROPHARMACOLOGY, 2009, 57 (5-6) :481-495

[10]

CHEN G, 1959, J PHARMACOL EXP THER, V127, P241

← 1 2 3 4 5 →