Bcl-2 family members: Essential players in skin cancer

被引：27
|
作者：
Nys, Kris [1 ]
Agostinis, Patrizia [1 ]
机构：
[1] Catholic Univ Louvain, Dept Mol Cell Biol, Cell Death Res & Therapy Unit, B-3000 Louvain, Belgium
来源：
CANCER LETTERS | 2012年 / 320卷 / 01期
关键词：
Skin; UVB; Skin cancer; Bcl-2; family; Apoptosis; SQUAMOUS-CELL CARCINOMA; UVB-INDUCED APOPTOSIS; HUMAN-MELANOMA CELLS; NERVE GROWTH-FACTOR; RADIATION-INDUCED APOPTOSIS; ULTRAVIOLET-B RADIATION; HUMAN MELANOCYTES; HUMAN KERATINOCYTES; UP-REGULATION; EPIDERMAL-KERATINOCYTES;
D O I：
10.1016/j.canlet.2012.01.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Skin cancer has reached epidemic proportions and is considered to be a direct consequence of ultraviolet (UV) radiation exposure. Excessive exposure of epidermal cells to UV results in apoptosis of irreparably damaged cells to avoid malignant transformation. The Bcl-2 family of proteins is emerging as a crucial regulator of epidermal homeostasis and cell's fate in the stressed skin. Not surprisingly, deregulation of Bcl-2 family members is also chiefly involved in skin carcinogenesis and response to cancer therapy. Here we discuss the physiopathological role of epidermal Bcl-2 family members, their implications in skin carcinogenesis and as potential targets in cancer therapy. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：1 / 13
页数：13
相关论文
共 50 条
  • [1] Role of Bcl-2 family members in invertebrates
    Igaki, T
    Miura, M
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3): : 73 - 81
  • [2] Bcl-2 family members as molecular targets in cancer therapy
    Marzo, Isabel
    Naval, Javier
    BIOCHEMICAL PHARMACOLOGY, 2008, 76 (08) : 939 - 946
  • [3] The role of Bcl-2 family members in tumorigenesis
    Kirkin, V
    Joos, S
    Zörnig, M
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3): : 229 - 249
  • [4] Attacking cancer's Achilles heel: antagonism of antiapoptotic BCL-2 family members
    Opferman, Joseph T.
    FEBS JOURNAL, 2016, 283 (14) : 2661 - 2675
  • [5] Control of proliferation by Bcl-2 family members
    Bonnefoy-Berard, N
    Aouacheria, A
    Verschelde, C
    Quemeneur, L
    Marcais, A
    Marvel, J
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3): : 159 - 168
  • [6] Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer
    Delehedde, M
    Cho, SH
    Sarkiss, M
    Brisbay, S
    Davies, M
    El-Naggar, AK
    McDonnell, TJ
    CANCER, 1999, 85 (07) : 1514 - 1522
  • [7] Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members
    Villanova, Lidia
    Careccia, Silvia
    De Maria, Ruggero
    Fiori, Micol E.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
  • [8] Bcl-2 family members and disease
    Sorenson, CM
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3): : 169 - 177
  • [9] Role of Bcl-2 family members in immunity and disease
    Droin, NM
    Green, DR
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3): : 179 - 188
  • [10] Therapeutic inhibition of BCL-2 and related family members
    Levy, Michelle A.
    Claxton, David F.
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2017, 26 (03) : 293 - 301
12345