Differential gene expression studies to explore the molecular pathophysiology of Down syndrome

被引：32

作者：

Antonarakis, SE

Lyle, R

Chrast, R

Scott, HS

机构：

[1] Univ Geneva, Sch Med, Ctr Med Univ, Div Med Genet, CH-1211 Geneva, Switzerland

[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[3] Walter & Eliza Hall Inst Med Res, Genet & Bioinformat Div, Melbourne, Vic 3050, Australia

来源：

BRAIN RESEARCH REVIEWS | 2001年 / 36卷 / 2-3期

关键词：

Down syndrome; animal model; gene expression; SAGE; microarray;

D O I：

10.1016/S0165-0173(01)00103-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trisomy 21, which causes Down syndrome, is the model human disorder due to the presence of a supernumerary chromosome. The completion of the sequence of chromosome 21 and the development of appropriate animal models now provide the molecular infrastructure and the reagents to elucidate the molecular mechanisms of the different phenotypes of Down syndrome. The study of the overexpression of single genes, and the dysregulation of global gene expression will enhance the understanding of the pathogenesis of the cognitive impairment of this syndrome. (C) 2001 Elsevier Science B.V. All rights reserved.

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收藏

页码：265 / 274

页数：10

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